Morphological analogies of fetal prostate stroma and stromal nodules in BPH

The Prostate
E BierhoffU Pfeifer

Abstract

A "reawakening" of ontogenetic processes in the development of BPH is still in debate. Therefore, morphological analogies of fetal prostate stroma and nodular stromal proliferates in BPH were investigated. Fetal prostates (n = 30; weeks 12-40 of gestation) and stromal nodules of benign prostatic hyperplasia (n = 375 from autopsies, n = 100 from biopsies) were investigated by histo- and immunohistochemistry with special regard to cytoskeletal (alpha-actin, desmin, myosin, and vimentin), neuronal (S-100 protein), neuroendocrine (neuron-specific enolase), leukocytic (CD3, CD20, and CD68) and vascular (CD34, BMA-120, and factor VIII) antigens. The developing fetal prostate stroma consists of immature mesenchymal cells up to week 17 of gestation, followed by fibroblastic and fibromuscular stromal cells up to week 25 of gestation and predominantly smooth-muscular cells until the end of gestation. Stromal nodules occur as immature mesenchymal, fibroblastic, fibromuscular, and smooth-muscular, suggestive of a maturational process. The fetal prostate stroma and the stromal nodules present, with an increasing degree of maturation, a similar vascular pattern and a similar occurrence of CD3 (T-lymphocytes), CD20 (B-lymphocytes), CD68 (macr...Continue Reading

Citations

Apr 2, 2014·Nature Reviews. Urology·Stephen F MurphyPraveen Thumbikat
Jun 12, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·G RobertA de La Taille
Dec 22, 2006·European Urology·Gero KramerMichael Marberger
Dec 22, 2004·The Prostate·Paul D WaldenAnindya Bhattacharya
Mar 30, 2011·The Prostate·Grégoire RobertJack A Schalken
Jun 11, 2009·International Journal of Andrology·B FibbiM Maggi
Sep 17, 2013·The Prostate·Camelia M SaffariniKim Boekelheide
Nov 16, 2004·The Journal of Urology·Keith L Lee, Donna M Peehl
Nov 17, 1998·The Journal of Urology·A M De MarzoD S Coffey
May 9, 2008·Differentiation; Research in Biological Diversity·Aubie ShawWade Bushman
Oct 12, 2000·The Prostate·D M Peehl, R G Sellers
Jan 25, 2017·Cancers·Damien A Leach, Grant Buchanan
Sep 4, 2008·Current Urology Reports·M Scott Lucia, James R Lambert
Nov 19, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saravana Mohan DhanasekaranArul M Chinnaiyan
Aug 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Georg E SteinerMichael Marberger
Feb 3, 2021·Developmental Biology·Diya B JosephDouglas W Strand
Jul 24, 2021·Nature Reviews. Urology·Gaelle FiardMark Emberton

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