Morphological analysis of patchy thickening and reddish discoloration of active hair growth areas in the skin of New Zealand White rabbits

Journal of Toxicologic Pathology
Tomoko IshiharaMinoru Sasaki

Abstract

Patchy thickening and reddish discoloration of active hair growth areas of skin in rabbits are occasionally found, and this gross feature could affect precise evaluation when conducting a dermal irritation test. Since little is known about the mechanism of this phenomenon, we examined the dorsal skin of New Zealand White rabbits morphologically and immunohistochemically in order to identify the possible mechanism responsible for developing these skin changes in relation to the hair cycle. Skin samples from 4 rabbits were divided into three groups (5 samples/group) based on their macroscopic characteristics: a thickened skin, erythematous skin, and smooth skin group. Histomorphological examination revealed that the percentage of hair follicles in the anagen phase, hair follicle length, hair follicle area, and proliferating cell nuclear antigen-positive cells in the hair follicles were greater in the thickened skin and erythematous skin groups than in the smooth skin group. Unlike mice and rats, the dermis was nearly adjacent to the muscular layer with a thin hypodermis, and the whole lengths of hair follicles in the anagen phase were located in the dermis in the rabbit skin. These results suggest that large hair follicles in the...Continue Reading

References

Oct 1, 1991·Jikken dobutsu. Experimental animals·T Anjiki, S Suzuki
Oct 1, 1994·Jikken dobutsu. Experimental animals·M Takeyoshi, M Koda
Apr 20, 2000·The Journal of Investigative Dermatology·L MecklenburgR Paus
Feb 22, 2001·The Journal of Clinical Investigation·K YanoM Detmar
Jul 10, 2001·The Journal of Investigative Dermatology·S Müller-RöverR Paus
Jan 1, 1986·Veterinary Clinical Pathology·G S ElliottA H Rebar
Jan 1, 2009·Folia Histochemica Et Cytobiologica·Wojciech Staniszewski
Feb 14, 2017·Journal of Toxicologic Pathology·Satoshi FurukawaKiyokazu Ozaki

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Citations

Jun 27, 2020·Colloids and Surfaces. B, Biointerfaces·Azza A HasanAmr S Abu Lila

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Methods Mentioned

BETA
biopsy

Software Mentioned

Aperio ImageScope

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