Morphological and Biochemical Characteristics of Prostate Hyperplasia during Sulpiride Treatment.

Bulletin of Experimental Biology and Medicine
I S TsvetkovV F Ostrov

Abstract

We studied morphological changes in the prostate ventral lobe, proliferative activity of the epithelium in prostate acini, and the levels of prolactin and prostate-specific antigen in the blood serum of Sprague-Dawley rats after repeated injections of sulpiride in a dose of 40 mg/ kg over 30 and 60 days and in 10 and 30 days after withdrawal. Morphological and morphometrical analysis of hyperplastic changes in the prostate ventral lobe was performed. Ki-67+ proliferating epithelial cells in the acini were counted. The dynamics of serum concentrations of prolactin and prostate-specific antigen was evaluated by ELISA. Morphological and morphometrical analysis and evaluation of the content of Ki-67+ cells demonstrated epithelium hyperplasia in the prostate ventral lobe after sulpiride treatment for 30 or 60 days and in 10 days after withdrawal, but serum level of prostate-specific antigen did not differ from the control. After 60-day sulpiride treatment and in 30 days after withdrawal, pronounced hyperplastic changes of prostate and elevated concentrations of prostate-specific antigen (but not prolactin) were observed. Thus, administration of sulpiride (40 mg/kg) to Sprague-Dawley rats for 60 days allows, by morphological criteria...Continue Reading

References

Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·F Van CoppenolleN Prevarskaya
Dec 22, 2006·European Urology·Gero KramerMichael Marberger
May 31, 2011·Differentiation; Research in Biological Diversity·Tristan M Nicholson, William A Ricke
Jan 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Petra PopovicsFerenc G Rick
Sep 26, 2017·Bulletin of Experimental Biology and Medicine·D Sh DzhalilovaO V Makarova

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