Morphological and biomolecular evidence for tuberculosis in 8th century AD skeletons from Bélmegyer-Csömöki domb, Hungary

Tuberculosis
Erika MolnárGyörgy Pálfi

Abstract

Macromorphological analysis of skeletons, from 20 selected graves of the 8th century AD Bélmegyer-Csömöki domb, revealed 19 cases of possible skeletal tuberculosis. Biomolecular analyses provided general support for such diagnoses, including the individual without pathology, but the data did not show coherent consistency over the range of biomarkers examined. Amplification of ancient DNA fragments found evidence for the Mycobacterium tuberculosis complex DNA only in five graves. In contrast, varying degrees of lipid biomarker presence were recorded in all except two of the skeletons, though most lipid components appeared to be somewhat degraded. Mycobacterial mycolic acid biomarkers were absent in five cases, but the weak, possibly degraded profiles for the remainder were smaller and inconclusive for either tuberculosis or leprosy. The most positive lipid biomarker evidence for tuberculosis was provided by mycolipenic acid, with 13 clear cases, supported by five distinct possible cases. Combinations of mycocerosic acids were present in all but three graves, but in one case a tuberculosis-leprosy co-infection was indicated. In two specimens with pathology, no lipid biomarker evidence was recorded, but one of these specimens prov...Continue Reading

References

May 1, 1990·The Journal of Infectious Diseases·K D EisenachJ T Crawford
Oct 24, 2000·American Journal of Physical Anthropology·C J HaasA G Nerlich
Jan 12, 2002·American Journal of Physical Anthropology·M Schultz
Jul 13, 2002·American Journal of Physical Anthropology·Israel HershkovitzBruce M Rothschild
Jun 15, 2007·BMC Veterinary Research·G Michael TaylorR Glyn Hewinson
May 3, 2011·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·S EvingerT Hajdu
Apr 18, 2013·Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur·Annamária PósaGyörgy Pálfi

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