Morphological and Cellular Features of Innate Immune Reaction in Helicobacter pylori Gastritis: A Brief Review

International Journal of Molecular Sciences
Antonio IeniRosario Alberto Caruso

Abstract

Innate and adaptive immunity are both involved in acute and chronic inflammatory processes. The main cellular players in the innate immune system are macrophages, mast cells, dendritic cells, neutrophils, eosinophils, and natural killer (NK), which offer antigen-independent defense against infection. Helicobacter pylori (H. pylori) infection presents peculiar characteristics in gastric mucosa infrequently occurring in other organs; its gastric colonization determines a causal role in both gastric carcinomas and mucosa-associated lymphoid tissue lymphoma. In contrast, an active role for Epstein-Barr virus (EBV) has been identified only in 9% of gastric carcinomas. The aim of the present review is to discuss the role of cellular morphological effectors in innate immunity during H. pylori infection and gastric carcinogenesis.

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Citations

Sep 7, 2016·International Journal of Molecular Sciences·Susanna Esposito
May 7, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Zahid HussainYeong Yeh Lee
Nov 25, 2016·Analytical Cellular Pathology (Amsterdam)·Antonio IeniGiovanni Tuccari
Aug 11, 2020·Journal of Immunology Research·Siru Nie, Yuan Yuan
Jun 14, 2019·Frontiers in Cellular and Infection Microbiology·Kristin L PatrickRobert O Watson

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