Morphological and cytochemical alterations of the Golgi apparatus and GERL in rat parotid acinar cells during ethionine intoxication and recovery

The American Journal of Anatomy
C OliverA R Hand

Abstract

The present electron microscopic cytochemical investigation was undertaken to characterize the alterations in the golgi apparatus and GERL of rat parotid acinar cells during ethionine intoxication and recovery. Although the Golgi apparatus and GERL were reduced in size, and some broadening of the Golgi saccules occurred as the result of ethionine treatment, the relative localization of thiamine pyrophosphatase (TPPase) activity in the Golgi saccules, and acid phosphatase activity (AcPase) in GERL, remained unchanged. Shortly after ethionine treatment was stopped, a dramatic redistribution of enzyme activities was noted. Within the first 24 hours of recovery, the Golgi apparatus began to enlarge, and the content of secretory granules increased. By day 3 of recovery, cisternae morphologically identifiable as GERL and forming secretory granules possessed TPPase activity, while AcPase activity was virtually undetectable. After seven days of recovery, the Golgi apparatus and GERL appeared both morphologically and cytochemically normal. The enzyme modulation observed during recovery may be correlated with increased secretory granule production. Furthermore, the presence of TPPase activity in GERL and forming secretory granules lends ...Continue Reading

References

Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A B Novikoff
Jun 1, 1979·The American Journal of Anatomy·C OliverA R Hand
Jan 1, 1977·The Journal of Cell Biology·L L ChuD V Cohn
Dec 1, 1977·Molecular Biology Reports·H H CzosnekA A Hochberg
Aug 29, 1978·Biochemical and Biophysical Research Communications·I J LeebR L Lundblad
Dec 28, 1978·Cell and Tissue Research·R B KellyA R Hand
May 1, 1977·The Journal of Cell Biology·H GainerM J Brownstein
Oct 1, 1977·Experimental Cell Research·R E Garfield, A P Somlyo
Sep 1, 1975·The Biochemical Journal·P F Swann
Jan 1, 1969·Journal of Ultrastructure Research·A R Spurr
Jun 1, 1969·Archives of Biochemistry and Biophysics·E A Smuckler, M Koplitz
Jun 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·A B NOVIKOFF, S GOLDFISCHER
Feb 1, 1962·The Journal of Cell Biology·B WEISBLUMP J FITZGERALD

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Citations

Sep 1, 1983·The Journal of Cell Biology·M Pavelka, A Ellinger
Nov 1, 1988·The American Journal of Anatomy·A RambourgL Hermo
Oct 1, 1985·The Anatomical Record·S Nicholas, R S Redman
Oct 5, 1987·Biochimica Et Biophysica Acta·J Roth

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