PMID: 9163604May 1, 1997Paper

Morphological and cytochemical findings in 150 cases of T-lineage acute lymphoblastic leukaemia in adults. German Multicentre ALL Study Group (GMALL)

British Journal of Haematology
W GassmannDieter Hoelzer

Abstract

We evaluated the morphological findings in 150 consecutive cases of T-lineage acute lymphocytic leukaemia (T-ALL). Cytochemistry including PAS staining and acid phosphatase reaction proved of limited value for the diagnosis of ALL. The diagnosis of acute leukaemia was easy to establish in most instances. However, in a few cases the leukaemic cells were difficult to recognize as blasts. The nuclei of such cells showed condensed chromatin and nucleoli were lacking, and was encountered particularly in thymic ALL. Basophilic cytoplasm combined with prominent vacuolization suggestive of mature B-ALL (ALL-L3 type), was observed in 16 cases. Other features, however, such as cell size, polymorphism, chromatin structure, sparse cytoplasm or focal positivity for acid phosphatase, excluded a diagnosis of ALL-L3 in those cases. Distinction from hybrid leukaemia was difficult in 20 cases, because of a low percentage of peroxidase-positive blasts or other features which suggested a separate myeloid leukaemia component. In nine of these the hybrid nature of the leukaemia was considered as certain on the basis of morphology. Seven cases had been diagnosed as biphenotypic with coexpression of myeloid and lymphoid markers by immunological techni...Continue Reading

Citations

Mar 21, 2007·American Journal of Clinical Pathology·Xin Han, Carlos E Bueso-Ramos
May 16, 2018·Annals of Occupational and Environmental Medicine·Jin-Ha YoonYeon-Soon Ahn
Jul 10, 2019·Computational Intelligence and Neuroscience·Tatdow PansombutAniruth Phon-On
Aug 8, 2008·Archives of Pathology & Laboratory Medicine·Brendan C DicksonJeffrey H Lipton
Jun 9, 2004·Critical Reviews in Oncology/hematology·Renato BassanRoel Willemze
Jan 9, 2001·Hematology/oncology Clinics of North America·R LaiC Bueso-Ramos
Aug 9, 2005·Annals of Diagnostic Pathology·Xin Han, Carlos E Bueso-Ramos

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