PMID: 9552125Apr 29, 1998Paper

Morphological and electrophysiological characteristics of noncholinergic basal forebrain neurons

The Journal of Comparative Neurology
K PangL Zaborszky

Abstract

Cholinergic neurons in the basal forebrain are the focus of considerable interest because they are severely affected in Alzheimer's disease. However, both cholinergic and noncholinergic neurons are intermingled in this region. The goal of the present study was to characterize the morphology and in vivo electrophysiology of noncholinergic basal forebrain neurons. Neurons in the ventral pallidum and substantia innominata were recorded extracellularly, labeled juxtacellularly with biocytin and characterized for the presence of choline acetyltransferase immunoreactivity. Two types of ventral pallidal cells were observed. Type I ventral pallidal neurons had axons that rarely branched near the cell body and tended to have smaller somata and lower spontaneous firing rates than did type II ventral pallidal neurons, which displayed extensive local axonal arborizations. Subtypes of substantia innominata neurons could not be distinguished based on axonal morphology. These noncholineregic neurons exhibited local axon arborizations along a continuum that varied from no local collaterals to quite extensive arbors. Substantia innominata neurons had lower spontaneous firing rates, more variable interspike intervals, and different spontaneous f...Continue Reading

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Citations

Feb 24, 2012·Journal of Neurophysiology·J M HawrylukE Arrigoni
Jul 23, 1999·Annals of the New York Academy of Sciences·L ZaborszkyI Kallo
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Jan 10, 2021·Communications Biology·Mahsa MoaddabMichael A McDannald

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