Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease.

The American Journal of Pathology
Zuzana SiskováV Hugh Perry

Abstract

Synaptic and dendritic pathology is a well-documented component of prion disease. In common with other neurodegenerative diseases that contain an element of protein misfolding, little is known about the underlying mechanisms of synaptic degeneration. In particular, in prion disease the relationship between synaptic malfunction, degeneration, and mitochondria has been neglected. We investigated a wide range of mitochondrial parameters, including changes in mitochondrial density, inner membrane ultrastructure, functional properties and nature of mitochondrial DNA from hippocampal tissue of mice with prion disease, which have ongoing synaptic pathology. Our results indicate that despite a lack of detectable changes in either mitochondrial density or expression of the mitochondrial proteins, mitochondrial function was impaired when compared with age-matched control animals. We observed changes in mitochondrial inner membrane morphology and a reduction in the cytochrome c oxidase activity relative to a sustained level of mitochondrial proteins such as porin and individual, functionally important subunits of complex II and complex IV. These data support the idea that mitochondrial dysfunction appears to occur due to inhibition or mod...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F CaronJ Rouvière-Yaniv
Apr 1, 1989·Journal of Virology·J M AikenR F Marsh
Jun 15, 1996·Annals of the New York Academy of Sciences·M TanakaT Ozawa
Aug 1, 1997·Biochemical Society Transactions·J P BolañosS J Heales
Nov 12, 1998·The American Journal of Pathology·E ArbustiniM Viganò
Jul 10, 1999·Free Radical Research·D W LeeH M Wisniewski
Mar 29, 2001·Journal of Neuropathology and Experimental Neurology·D T WalshV H Perry
Dec 18, 2001·Journal of Neuroscience Research·G A PerkinsM H Ellisman
Feb 16, 2002·Biochemical and Biophysical Research Communications·Gino MieleMichael Clinton
Oct 9, 2002·Neuropathology and Applied Neurobiology·D A CottrellD M Turnbull
Oct 23, 2002·Journal of Neuroscience Research·Rudy CastellaniMark A Smith
Jun 6, 2003·The European Journal of Neuroscience·C CunninghamV H Perry
Jun 27, 2003·The New England Journal of Medicine·Salvatore DiMauro, Eric A Schon
Jul 10, 2003·Lancet Neurology·Kenneth J Smith, Hans Lassmann
Aug 26, 1961·Nature·A N DAVISON, J DOBBING
Mar 1, 1955·The Journal of Biophysical and Biochemical Cytology·R F WITTERM A COTTONE
Nov 1, 2003·Science·Ted M Dawson, Valina L Dawson
Jun 4, 2004·Neuropathology and Applied Neurobiology·C W Picanço-DinizC Cunningham
Feb 8, 2005·Neuroscience Letters·Bruno Lobão-SoaresRoger Walz
Mar 19, 2005·Brain : a Journal of Neurology·Christine StadelmannHans Lassmann
Apr 30, 2005·Nature Reviews. Genetics·Robert W Taylor, Doug M Turnbull
Sep 24, 2005·Annals of Neurology·M Flint Beal
Oct 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colm CunninghamV Hugh Perry
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Donghui ZhuJames C-M Lee
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin FuhrmannJochen Herms
Nov 15, 2007·Journal of Neurochemistry·Andrew W J PatersonNikki K Macleod
Feb 21, 2008·Annual Review of Neuroscience·Jennifer N Bourne, Kristen M Harris
Jun 3, 2008·Brain : a Journal of Neurology·Don MahadDouglas Turnbull
Aug 19, 2008·Brain Research·Ayodeji A AsuniVincent O'Connor
Dec 17, 2008·Annals of the New York Academy of Sciences·Amy K ReeveDoug Turnbull
Dec 17, 2008·Annals of the New York Academy of Sciences·Carmen A Mannella
Dec 17, 2008·Neuron·Mark P MattsonAiwu Cheng

❮ Previous
Next ❯

Citations

Apr 13, 2013·Disease Models & Mechanisms·Layla SinclairCathryn L Haigh
Jan 26, 2013·PloS One·Shaheen AkhtarSarah E Lloyd
Feb 19, 2011·International Journal of Alzheimer's Disease·Fiorella Malchiodi-AlbediMarco Diociaiuti
Sep 24, 2014·Nature Reviews. Neurology·Mark R Baker
Mar 29, 2014·European Journal of Human Genetics : EJHG·Jin ZhangXiao-Ping Dong
Nov 12, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shu-Xun LiuBo-Lin Zhang
Feb 2, 2013·Neuroscience Letters·Ayodeji A AsuniMartin J Sadowski
Dec 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irina MilisavSamo Ribarič
Apr 14, 2011·Journal of Neuropathology and Experimental Neurology·Anne-Laure J MougenotThierry G Baron
Sep 19, 2015·Redox Biology·Marta PajaresAntonio Cuadrado
Feb 18, 2012·Journal of Pineal Research·Jae-Kyo JeongSang-Youel Park
Jan 8, 2013·Neuropathology and Applied Neurobiology·T H Gillingwater, T M Wishart
Sep 26, 2012·Phytotherapy Research : PTR·Jae-Kyo JeongSang-Youel Park
Oct 21, 2015·Communicative & Integrative Biology·Gianni Guizzunti, Chiara Zurzolo
Mar 27, 2015·Journal of Pineal Research·Jae-Kyo Jeong, Sang-Youel Park
Apr 24, 2014·Biochemical and Biophysical Research Communications·Hong-Seok ChoiYong-Sun Kim
Feb 17, 2015·Virus Research·Susan F GodsaveHolger Wille
Jun 10, 2011·Communicative & Integrative Biology·Marie-Ève Tremblay, Ania K Majewska
Mar 16, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Sheroy MinocherhomjiKeshav K Singh
Oct 16, 2010·Prion·Keith M GunapalaAndrew D Steele
Jun 22, 2013·Prion·Teresa M Gunn, George A Carlson
Jul 16, 2013·Neurobiology of Learning and Memory·Gary P MorrisBryce Vissel
Dec 2, 2014·International Journal of Molecular Medicine·Ji-Hong Moon, Sang-Youel Park
May 12, 2012·Neurobiology of Aging·Jae-Kyo JeongSang-Youel Park
Apr 14, 2016·The Journal of Comparative Neurology·Matthew A SmithSamuel D Crish
Nov 2, 2016·Journal of Alzheimer's Disease : JAD·Isaura V A MartinsCatherine B Lawrence
Mar 6, 2013·Acta Biochimica Et Biophysica Sinica·Hao YaoLifeng Yang
Jun 29, 2016·Brain Pathology·Markus Glatzel, Diego Sepulveda-Falla
Feb 6, 2017·Scientific Reports·Robert FarisSuzette A Priola
Jul 1, 2017·Journal of Virology·Robert FarisSuzette A Priola
Aug 2, 2017·The Journal of General Virology·James A CarrollBruce Chesebro
Mar 22, 2015·Expert Review of Proteomics·Roger A MooreSuzette A Priola
Nov 19, 2011·Expert Review of Neurotherapeutics·Alexandra I MotMarcus W Brazier
Dec 7, 2016·Journal of Molecular Neuroscience : MN·Xiao -Dong YangXiao-Ping Dong
Dec 10, 2016·Cold Spring Harbor Protocols·Lisa C CrowleyNigel J Waterhouse
May 16, 2019·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Teresa M GunnBritney Gibbs
Apr 18, 2020·Acta Neuropathologica Communications·Irene H FlønesCharalampos Tzoulis
Dec 17, 2014·The Journal of Biological Chemistry·Belinda B GuoAndrew F Hill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

© 2021 Meta ULC. All rights reserved