Morphological and functional analyses of adult onset vitelliform macular dystrophy

The British Journal of Ophthalmology
W SaitoK Ogata

Abstract

To evaluate the morphology and visual function of the macula in eyes with adult onset vitelliform macular dystrophy (AVMD). 12 eyes of six patients with AVMD were examined by ophthalmoscopy, scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), and multifocal electroretinography (mfERGs). The macular lesions were bilateral in all patients and varied from the typical vitelliform (five eyes), faded vitelliform changes with retinal pigment epithelium (RPE) atrophy (five eyes), and a normal fovea associated with small flecks around the macula (two eyes). SLO demonstrated small abnormal bright spots in the deep retina throughout the posterior retina in all cases. OCT showed a highly reflective fusiform thickened layer at the level of the RPE and choriocapillaris in patients with a submacular yellow vitelliform lesion. A well circumscribed, optically clear space was observed beneath the retinal layer in the macular lesions with RPE atrophy. The mfERGs were significantly reduced not only in the macular area but also in the outermost ring (20-30 degrees ) of the mfERGs. The submacular materials that accumulate within the RPE or subepithelial layers reported in previous histopathological studies of vitelliform lesions...Continue Reading

References

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Citations

Jan 1, 2010·Documenta Ophthalmologica. Advances in Ophthalmology·Elizabeth A DaleJeffrey G Odel
Nov 15, 2011·Retina·Christine Nichols KaySteven Myles Cohen
Apr 21, 2009·Progress in Retinal and Eye Research·Camiel J F BoonAnneke I den Hollander
Jan 11, 2007·Survey of Ophthalmology·Timothy Y Y LaiDennis S C Lam
Mar 29, 2006·Optometry : Journal of the American Optometric Association·Philip Do, Steven Ferrucci
Feb 15, 2015·Progress in Retinal and Eye Research·Itay ChowersCamiel J F Boon
May 23, 2008·Progress in Retinal and Eye Research·Adrian Gh Podoleanu, Richard B Rosen
May 21, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Seanna GrobDean Eliott
Jan 5, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Christiane Al-HaddadHasan Chahine

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