Morphological and Functional Assessment of Oesophageal Mucosa Integrity in Children With Cystic Fibrosis

Journal of Pediatric Gastroenterology and Nutrition
Jernej BreceljRok Orel

Abstract

The aim of the study was to investigate morphological and functional characteristics of oesophageal epithelial barrier in children with cystic fibrosis (CF) with or without gastro-oesophageal reflux disease (GORD) in comparison to healthy controls. Oesophagogastroduodenoscopy with oesophageal biopsies and combined oesophageal multichannel intraluminal impedance-pH monitoring was performed in 17 children with CF (CFtot) with (CFgord) or without GORD (CFnorm). Histological combined severity score was calculated and widths of spaces between epithelial cells were measured. Basal impedance value was used to assess functional integrity of epithelial barrier. Results of each investigation were compared with a group of children without oesophageal disease. CFtot, but also CFnorm, had more severe pathohistological changes included in the compound severity score than controls (0.75 ± 0.32 and 0.75 ± 0.20 vs 0.27 ± 0.25; P < 0.001 and P = 0.001, respectively). They also had more dilated intercellular spaces (2.6 μm ± 0.6 and 2.7 μm ± 0.5 vs 1.9 μm ± 0.2; P = 0.001 and P < 0.001, respectively). Baseline impedance values between proximal and distal pairs of electrodes were significantly lower in CFtot (2876 Ω ± 484, 2590 Ω ± 1013) and also ...Continue Reading

References

May 1, 1992·The Journal of Pediatrics·D R MackJ A Perman
Feb 1, 1989·Journal of Pediatric Gastroenterology and Nutrition·M S MurphyR Nelson
Apr 1, 1989·Gastroenterology·R C OrlandoM R Knowles
Nov 1, 1986·Archives of Disease in Childhood·D J PennyS M Basheer
Sep 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·K HallbergB Strandvik
Oct 11, 2001·Journal of Pediatric Gastroenterology and Nutrition·H J HendriksP P Forget
Jan 28, 2003·Journal of Pediatric Gastroenterology and Nutrition·Rok Orel, Sasa Markovic
Dec 23, 2003·The American Journal of Gastroenterology·N A TobeyR C Orlando
Apr 21, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Rok Orel, Gaj Vidmar
Dec 14, 2007·The American Journal of Gastroenterology·Hannah van MalensteinDaniel Sifrim
Dec 25, 2007·Gastrointestinal Endoscopy·Kenneth K LeeTrina Van Guilder
Jun 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·Yvan VandenplasHendrik Reynaert
Oct 12, 2010·American Journal of Physiology. Cell Physiology·Paul M Quinton
Apr 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Solange Abdulnour-NakhoulNazih L Nakhoul
Jun 18, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·K De BoeckUNKNOWN EuroCareCF WP3 Group on CF diagnosis
Dec 14, 2011·Journal of Pediatric Gastroenterology and Nutrition·Jernej BreceljRok Orel
Jun 20, 2012·Journal of Pediatric Gastroenterology and Nutrition·Tobias G WenzlUNKNOWN ESPGHAN EURO-PIG Working Group
Jul 11, 2012·The American Journal of Gastroenterology·Ans PauwelsDaniel Sifrim
Sep 15, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Valentina ManciniOsvaldo Borrelli
Jan 16, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D UmmarinoY Vandenplas
Jul 17, 2013·Journal of Pediatric Gastroenterology and Nutrition·Simon H MurchAlexandra Papadopoulou
May 24, 2014·Journal of Pediatric Surgery·Tamara CaldaroLuigi Dall'Oglio
Jun 14, 2014·American Journal of Respiratory and Critical Care Medicine·Steven M RoweUNKNOWN GOAL Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network
Jul 16, 2014·Journal of Pediatric Gastroenterology and Nutrition·Alberto RavelliMarianna Salemme

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

United European Gastroenterology Journal
Bram D van RhijnAlbert J Bredenoord
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Bruno HauserYvan Vandenplas
The American Journal of Gastroenterology
Boudewijn F KessingA J P M Smout
© 2021 Meta ULC. All rights reserved