Morphological and functional changes of chronic pancreatitis in patients with dyspepsia: A prospective, observational, cross-sectional study

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
José Lariño-NoiaJ Enrique Domínguez-Muñoz

Abstract

Whether chronic pancreatitis (CP) may present with dyspepsia is controversial. We aimed at evaluating the frequency and risk factors of changes of CP in patients presenting with epigastric pain syndrome (EPS)-like symptoms. A prospective, observational, cross-sectional study was carried out in patients with EPS-like symptoms. Patients underwent endoscopic ultrasound (EUS) evaluation of the pancreas, and changes of CP were defined as the presence of five or more EUS criteria of the disease. In patients with 3 or 4 EUS criteria, magnetic resonance dynamic evaluation of the pancreas (MRI/sMRCP) and endoscopic pancreatic function test (ePFT) were carried out to confirm or exclude the presence of changes of CP. A multivariate logistic regression analysis was performed to evaluate factors associated with CP findings, and results are shown as odds ratio (OR) and 95% confidence interval (CI). 213 patients were included. Changes of CP were confirmed by EUS (≥5 criteria) in 18 patients (8.4%). Thirty-four patients had 3-4 EUS criteria, and changes of CP were confirmed in 27 of them by MRI/sMRCP and ePFT (12.7%). Morphological and functional findings of CP were then present in 45 patients (21.1%). Male gender (OR 2.97; 95%CI 1.39-6.37) an...Continue Reading

Citations

Sep 11, 2018·Current Opinion in Gastroenterology·Jan TackFlorencia Carbone
May 15, 2019·The American Journal of Gastroenterology·Mahya Faghih, Vikesh K Singh
Jun 20, 2018·Journal of Clinical Medicine·Mustafa TahtaciOsman Ersoy
Dec 21, 2019·JAMA : the Journal of the American Medical Association·Vikesh K SinghPramod K Garg
Jun 28, 2020·Current Gastroenterology Reports·Mahendran JayarajGordon Ohning
Jul 1, 2020·Terapevticheskiĭ arkhiv·I V KozlovaM A Osadchuk
Aug 31, 2021·The American Journal of Gastroenterology·Mahya FaghihVikesh K Singh

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