Morphological and functional properties of the conducting human airways investigated by in vivo computed tomography and in vitro MRI

Journal of Applied Physiology
Tristan Van de MoorteleFilippo Coletti

Abstract

The accurate representation of the human airway anatomy is crucial for understanding and modeling the structure-function relationship in both healthy and diseased lungs. The present knowledge in this area is based on morphometric studies of excised lung casts, partially complemented by in vivo studies in which computed tomography (CT) was used on a small number of subjects. In the present study, we analyzed CT scans of a cohort of healthy subjects and obtained comprehensive morphometric information down to the seventh generation of bronchial branching, including airway diameter, length, branching angle, and rotation angle. Although some of the geometric parameters (such as the child-to-parent branch diameter ratio) are found to be in line with accepted values, for others (such as the branch length-to-diameter ratio) our findings challenge the common assumptions. We also evaluated several metrics of self-similarity, including the fractal dimension of the airway tree. Additionally, we used phase-contrast magnetic resonance imaging (MRI) to obtain the volumetric flow field in the three-dimensional-printed airway model of one of the subjects during steady inhalation. This is used to relate structural and functional parameters and, ...Continue Reading

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Citations

Jan 10, 2020·Journal of Applied Physiology·Robb W GlennyReinhard R Beichel
Jan 16, 2020·International Journal of Environmental Research and Public Health·Mohammad S IslamSuvash C Saha
Jun 6, 2019·Annals of Biomedical Engineering·Omid AmiliFilippo Coletti
Jan 8, 2021·Frontiers in Physiology·Naoya TanabeToyohiro Hirai

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