PMID: 8580731Nov 1, 1995Paper

Morphological and functional study of extensor digitorum longus muscle regeneration after iterative crush lesions in mdx mouse

Neuromuscular Disorders : NMD
J P LouboutinM Fardeau

Abstract

The regenerative capacity of mdx Extensor Digitorum Longus (EDL) muscle after iterative muscle crush injuries was examined and compared with that of age-matched control C57BL/10 mice. Muscle crush injuries were performed at 8 weeks and repeated at 12 and 16 weeks. Contralateral non-crushed EDLs from mdx and C57BL/10 mice were used as internal controls for histopathology, histoenzymology, morphometry and for the study of the contractile properties. Morphological examinations were performed at 12, 16 and 20 weeks, respectively one month after a single, a second or a third crush. Contractile properties were studied at 12 to 20 weeks. By 20 weeks, no difference in the number of fibres with internal nuclei could be observed between crushed EDL from both strains, and non-crushed mdx EDL; the area and the diameter of crushed EDL from mdx mice were, respectively, 1.5- and 1.2-fold higher than the ones from crushed EDL from C57BL/10 strain. By 20 weeks, diameter distribution of crushed EDL muscles from C57BL/10 mice were shifted towards smaller fibre diameter, whereas in mdx mice, diameter distribution of crushed EDL muscles paralleled that of non-crushed EDL muscles. By 20 weeks, crushed mdx and C57BL/10 EDL muscles produced 77 and 47%...Continue Reading

References

Oct 1, 1992·Muscle & Nerve·E E Dupont-Versteegden, R J McCarter
Sep 1, 1992·Journal of the Neurological Sciences·P MoensG Maréchal
Jul 1, 1992·Muscle & Nerve·J G QuinlanS P Lyden
Mar 1, 1992·Muscle & Nerve·C L Mechalchuk, B H Bressler
Dec 1, 1988·Journal of Muscle Research and Cell Motility·J E AndersonW K Ovalle
Apr 1, 1986·Journal of Muscle Research and Cell Motility·E GhinsG Marechal
Jun 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M H Brooke, K K Kaiser
Aug 1, 1972·Experimental Neurology·B M Carlson, E Gutmann
Nov 1, 1984·Muscle & Nerve·J Dangain, G Vrbova
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G BulfieldK J Moore
Sep 1, 1993·Neuromuscular Disorders : NMD·J P LouboutinM Fardeau
Jan 1, 1961·The Journal of Biophysical and Biochemical Cytology·A B NOVIKOFFJ DRUCKER
May 1, 1955·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H A PADYKULA, E HERMAN

❮ Previous
Next ❯

Citations

Mar 1, 1997·Neuromuscular Disorders : NMD·A IrintchevA Wernig
Sep 15, 2012·Cell Death and Differentiation·S KangE S Alnemri
Mar 27, 2012·BMC Musculoskeletal Disorders·Simon HauerslevThomas O Krag
Jul 21, 2009·Muscle & Nerve·Kristen A BaltgalvisDawn A Lowe
Feb 16, 2013·Acta Neurologica Scandinavica·S HauerslevT O Krag
Apr 14, 2012·Muscle & Nerve·Fernando Jiménez-DíazJosé Peña
Mar 29, 2005·The American Journal of Pathology·Leah J HarcourtGordon S Lynch
Oct 23, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V B MinamotoT F Salvini
Jun 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stefan MateckiBasil J Petrof
Oct 26, 2010·Journal of Muscle Research and Cell Motility·Ian Curtis SmithRene Vandenboom
Jan 1, 2012·Current Protocols in Mouse Biology·Bernadett Kalmar, Linda Greensmith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.