Morphological and hemodynamic magnetic resonance assessment of early neonatal brain injury in a piglet model

Journal of Magnetic Resonance Imaging : JMRI
Berit H MunkebyA Bjørnerud

Abstract

To investigate the utility of functional and morphological magnetic resonance imaging (MRI) to assess the extent of brain injury in a hypoxia-ischemia (HI) piglet model and further to validate that the desired ischemic injury was successfully induced. MRI was performed at 1.5 T in anesthetized piglets (N = 10, age = 12-36 hours). Relative cerebral blood flow (rCBF), time-to-peak (TTP) contrast, and apparent diffusion coefficient (ADC) were estimated at different time points pre-, during, and post-HI. The effect following bilateral clamping of the carotid arteries was assessed by contrast-enhanced MR angiography (MRA) and phase contrast MR angiography (PCA) (N = 4). A linear correlation was observed between relative cerebral perfusion reduction and cerebral ADC during HI (r(2) = 0.85, P < 0.05). There was no correlation between rCBF reduction during 30 minutes of HI and cerebral ADC after 30 or 150 minutes of reperfusion/reoxygenation (RR). The combination of morphological and functional (perfusion and diffusion) MRI enabled consistent assessment of both the presence and absence of complete occlusion as well as the functional significance of the occlusion.

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Citations

Jun 20, 2013·European Journal of Radiology·QiangQiang GangYikai Xu
Apr 20, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander DrobyshevskySidhartha Tan
Jun 27, 2007·Nuclear Medicine and Biology·Birte DrewesHeinz H Coenen
Apr 21, 2007·Neuroscience and Biobehavioral Reviews·Nanna Marie LindAxel K Hansen
Oct 26, 2006·Journal of Anatomy·Berit H MunkebyInge Bjerkås
Feb 17, 2015·Ultrasound in Medicine & Biology·Caryn A UrbanczykCameron R Bass
Nov 12, 2014·Annual Review of Animal Biosciences·Matthew S Conrad, Rodney W Johnson
Mar 16, 2007·Journal of the American Chemical Society·Shizhong WangAngelique Y Louie

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