Morphological and immunohistochemical assessment of intrahepatic bile duct development in the rat

Journal of Gastroenterology and Hepatology
J A Gall, P S Bhathal

Abstract

The hypotheses that intrahepatic bile ducts are derived either by a transformation of periportal liver cells or by dichotomous branching of the extrahepatic bile ducts were investigated in fetal and postnatal rat livers by histological and immunohistochemical methods using an antiserum to prekeratin which, in the liver, binds to biliary epithelial cells (BEC). In conventionally stained sections, bile duct development was observed to begin in the 19 day fetus around the larger branches of the portal vein, with the formation of lumina surrounded by cuboidal or elongated hepatoblast-like cells on the portal aspect and readily distinguished hepatoblasts on the lobular aspect. At 21 days, these structures had developed into canals of Hering lined jointly by recognizable liver cells and BEC. The number of canals of Hering per portal tract peaked at 22 days' gestation and diminished in number at birth and over the ensuing 56 h, with a concomitant increase in fully formed ducts. Bile ducts lined completely by BEC were first found at 20 days. Immunohistochemically, prekeratin antigens were first detected at 20 days in duct-like structures not only in phenotypic BEC but also in adjacent cells with an hepatoblast phenotype. Such intermedi...Continue Reading

References

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Citations

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MitakaY Mochizuki
Apr 29, 1998·In Vitro Cellular & Developmental Biology. Animal·A S FiorinoL M Reid
May 27, 2004·The American Journal of Pathology·Sandeep S SekhonSatdarshan P S Monga
Jan 1, 1996·Toxicologic Pathology·W C Hall, J L Rojko
Feb 12, 1998·The Anatomical Record·V Vijayan, C E Tan
Jan 4, 1998·Microscopy Research and Technique·N Shiojiri
Jun 23, 2011·European Journal of Gastroenterology & Hepatology·Diva Carvalho Collarile Yamaguti, Francy Reis da Silva Patrício
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetR Sciot
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J Desmet
Jun 1, 1992·Histopathology·V J Desmet
Jun 1, 1993·Liver·P Van Eyken, V J Desmet

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