Morphological and inflammatory changes in visceral adipose tissue during obesity

Endocrine Pathology
Xavier S ReveloDaniel A Winer

Abstract

Obesity is a major health burden worldwide and is a major factor in the development of insulin resistance and metabolic complications such as type II diabetes. Chronic nutrient excess leads to visceral adipose tissue (VAT) expansion and dysfunction in an active process that involves the adipocytes, their supporting matrix, and immune cell infiltrates. These changes contribute to adipose tissue hypoxia, adipocyte cell stress, and ultimately cell death. Accumulation of lymphocytes, macrophages, and other immune cells around dying adipocytes forms the so-called "crown-like structure", a histological hallmark of VAT in obesity. Cross talk between immune cells in adipose tissue dictates the overall inflammatory response, ultimately leading to the production of pro-inflammatory mediators which directly induce insulin resistance in VAT. In this review, we summarize recent studies demonstrating the dramatic changes that occur in visceral adipose tissue during obesity leading to low-grade chronic inflammation and metabolic disease.

References

May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G L Wang, G L Semenza
Sep 27, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K LolmèdeA Bouloumié
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
May 25, 2004·Circulation Research·Ebba BråkenhielmYihai Cao
Nov 29, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Peter Arner
Dec 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Thomas SkurkHans Hauner
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Mar 31, 2007·Diabetes·Naomi HosogaiIichiro Shimomura
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jianping YeQing He
Sep 6, 2007·The Journal of Clinical Investigation·Yihai Cao
Sep 13, 2007·Diabetes·Katherine J StrisselMartin S Obin
Sep 27, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M E RauschD V Tortoriello
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Machteld M TiemessenLeonie S Taams
May 6, 2008·Nature·Kirsty L SpaldingPeter Arner
May 27, 2008·Journal of Lipid Research·Vered Elgazar-CarmonRachel Levy
Dec 31, 2008·Molecular and Cellular Biology·Tayeba KhanPhilipp E Scherer
Jan 13, 2009·Current Opinion in Lipidology·Julia Szendroedi, Michael Roden
May 9, 2009·Biochemical and Biophysical Research Communications·Carine DuffautAnne Bouloumié
Jul 28, 2009·Nature Medicine·Shawn WinerH-Michael Dosch
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Magdalena PasaricaSteven R Smith
Jan 29, 2010·Cellular and Molecular Life Sciences : CMLS·Edwin C M Mariman, Ping Wang
Feb 13, 2010·Annual Review of Physiology·Jerrold M Olefsky, Christopher K Glass
Apr 13, 2010·Diabetologia·M JagannathanB S Nikolajczyk
May 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yaron IlanHoward L Weiner
May 18, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Henrike Sell, Jürgen Eckel
Jun 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyunwon YangVishwa Deep Dixit
Oct 5, 2010·Mediators of Inflammation·Oreste Gualillo

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Citations

Dec 3, 2014·Tissue & Cell·G ContiA Sbarbati
Nov 28, 2015·Obesity·Curtis Perriotte-OlsonViswanathan Saraswathi
Dec 30, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L-G HersougS Loft
Jun 30, 2015·Canadian Journal of Physiology and Pharmacology·Jerzy BełtowskiKrzysztof Hałas
Jul 5, 2015·BMC Anesthesiology·Vilma E Ortiz, Jean Kwo
Aug 28, 2015·Journal of Gastroenterology and Hepatology·Jae Gu JungHyoun Woo Kang
Mar 16, 2017·Clinical Obesity·M PoddarV T Chetty
Jan 15, 2015·The American Journal of Gastroenterology·Chang Geun LeeHyoun Woo Kang
Apr 25, 2019·Journal of the American Heart Association·Ian J NeelandRenée de Mutsert
Dec 16, 2017·Nutrition Reviews·Clare F DixOlivia R L Wright
Aug 3, 2017·World Journal of Gastroenterology : WJG·Yves M BorbélyRoman A Inglin
Apr 5, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Yi-Hsuan LinDaniel A Winer
Mar 19, 2020·Cells·Justin Hou Ming Yung, Adria Giacca
Dec 17, 2020·International Journal of Molecular Sciences·Paweł GutajEwa Wender-Ozegowska
Sep 11, 2021·Scientific Reports·Fatemeh AshrafianSeyed Davar Siadat

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