PMID: 3214478Nov 1, 1988Paper

Morphological and kinetic abnormalities of platelets in hypercholesterolemic rabbits

Atherosclerosis
E MazoyerK Brennan

Abstract

Hypercholesterolemia (HC = hypercholesterolemia or hypercholesterolemic) was produced in rabbits by feeding them diets supplemented with cholesterol and peanut oil. Platelet counts and volumes, white cell counts, reticulocyte counts, and hematocrits were determined at intervals for 8-12 weeks in blood from HC animals and controls on a normal rabbit diet. Microthrombocytosis was a consistent occurrence in the presence of HC, developing as early as 2 weeks into the diet. Microthrombocytosis was generally associated with normal platelet counts, but mild thrombocytosis occurred late in the diet at the time of the highest levels of serum cholesterol (greater than 1300 mg/dl). Platelets from HC rabbits were morphologically normal by transmission electron microscopy. Survivals of 51Cr-labeled platelets from HC and non-HC rabbits were measured in HC and non-HC recipients. The results identified an intrinsic defect in the ability of HC platelets to survive in the circulation. They also confirmed previous findings of an environmental defect in HC that causes shortened platelet survival.

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Citations

Sep 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·M A PackhamR L Kinlough-Rathbone
Oct 1, 1996·European Journal of Clinical Investigation·I García-BolaoD Martínez-Caro
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P L GrossM A Packham

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