Morphological and molecular response of small intestine to lactulose and hydrogen-rich water in female piglets fed Fusarium mycotoxins contaminated diet

Journal of Animal Science and Biotechnology
Xu JiWen Yao

Abstract

Following the intake of Fusarium mycotoxin-contaminated feed, small intestines may be exposed to high levels of toxic substances that can potentially damage intestinal functions in livestock. It is well known that Fusarium mycotoxins will lead a breakdown of the normally impeccable epithelial barrier, resulting in the development of a "leaky" gut. H2 administration with different methods has been proved definitely potentials to prevent serious intestinal diseases. The goal of this study is to investigate the roles of lactulose (LAC) and hydrogen-rich water (HRW) in preventing intestinal dysfunction in piglets fed Fusarium mycotoxin-contaminated feed. A total of 24 female piglets were evenly assigned to 4 groups: negative control (NC) group, mycotoxin-contaminated (MC) feed group, MC feed with LAC treatment (MC + LAC), and MC feed with HRW treatment (MC + HRW), respectively. Piglets in the NC group were fed uncontaminated control diet, while remaining piglets were fed Fusarium mycotoxin-contaminated diet. For the NC and MC groups, 10 mL/kg body weight (BW) of hydrogen-free water (HFW) was orally administrated to piglets twice daily; while in the MC + LAC and MC + HRW groups, piglets were treated with the same dose of LAC solutio...Continue Reading

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Citations

Oct 21, 2020·Neuroscience Bulletin·Wei ChenShu-Cun Qin
Nov 6, 2020·Journal of Zhejiang University. Science. B·Yue-Qiao WangWen-Biao Shen
Jun 11, 2021·Toxicon : Official Journal of the International Society on Toxinology·Tayebe AziziAmir Tukmechi
Jul 11, 2021·Journal of Animal Science and Biotechnology·Ling ZhaoLvhui Sun

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Methods Mentioned

BETA
Assay
PCR
protein assay

Software Mentioned

Quantity One
SPSS
Image
Pro Plus

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