Morphological and morphometric analysis on the rabbit conjunctival goblet cells in different hormonal conditions

Experimental Eye Research
P AragonaD Britti

Abstract

An altered conjunctival mucous secretion was reported in pregnancy or oral contraceptive use. Four groups of rabbits (males, dioestrous females, oestrous females, pregnant) were studied to determine whether sex and/or different physiological conditions could influence conjunctival goblet cells structure and ultrastructure. Light microscopy, transmission electron microscopy, and morphometry were performed. In males and in oestrous females the intracytoplasmic secretory granules were filled with granular material, whilst in pregnant and dioestrous females the granules were formed by a more homogenous and dense secretory material. The number of goblet cells was not statistically different in the groups studied, whilst pregnant animals showed the largest mean diameter. As to the secretory granules, their mean area was larger in dioestrous females, whilst their optical density was highest in pregnant animals. These observations indicate that the morphology of conjunctival goblet cell may vary according to sex and to different physiological conditions: this may account for the peculiar mucous secretion demonstrated during pregnancy.

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Citations

Nov 4, 2015·Menopause : the Journal of the North American Menopause Society·Intira SriprasertFrank Z Stanczyk
Dec 4, 2004·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael J Doughty, Jan P G Bergmanson
Apr 3, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Susan TruongBlanka Golebiowski
Sep 14, 2007·Ophthalmic Research·Pasquale AragonaDomenico Puzzolo
Nov 14, 2012·Cornea·Johanna T HenrikssonJan P G Bergmanson
Apr 5, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Maurizio Rolando, Aldo Vagge
Dec 12, 2012·European Journal of Ophthalmology·Pasquale AragonaDomenico Puzzolo

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