Morphological and neurophysiological impairment of the nerve in type II macrodactyly

PloS One
Xi YangBin Wang

Abstract

Macrodactyly is a congenital malformation characterized by aggressive overgrowth of multiple tissues, including subcutaneous fat, nerves, and bones in digits or limbs. In type II macrodactyly, the peripheral nerve is enlarged; however, the morphological and functional characteristics of the affected peripheral nerves have rarely been evaluated. In this research, six macrodactyly patients and three polydactyly patients (control) were studied. Pre-operative sensory nerve action potential and intra-operative nerve action potential tests were performed. The microstructure and ultrastructure of the enlarged nerves were observed and neurofilament (NF) expression was evaluated using immunofluorescent staining. Axon impairment of the digital nerves originating from the median nerve (MN) was observed. A compensatory reinnervation from the ulnar nerve (UN) was found in two of the six patients, and significant morphological changes were observed in the enlarged nerve. The myelinated nerve fibers decreased, the lamellar structure of the myelin sheath changed, and the density of the NFs of the unmyelinated fibers decreased. There was aberrant distribution of NFs in the macrodactylous nerve tissues. In patients with compensatory UN reinnerva...Continue Reading

References

Jan 1, 1996·Annual Review of Neuroscience·M K Lee, D W Cleveland
Feb 24, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert A BolandMatthew C Kiernan
Nov 26, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Mohammad-Javad FatemiAydin H Pooli
May 30, 2009·Journal of Cutaneous Pathology·Kusuma VenkateshSridhar Murthy
Feb 18, 2010·Journal of Plastic Surgery and Hand Surgery·Gülden AvciTayfun Akoz
Jun 28, 2012·The Journal of Hand Surgery, European Volume·J HardwickeR Lester
Oct 27, 2012·Human Molecular Genetics·Jonathan J RiosMarybeth Ezaki
Sep 26, 2013·The Journal of Hand Surgery·Felecia CerratoBrian I Labow
Jan 1, 2014·Plastic and Reconstructive Surgery·Reid A MaclellanKyle C Kurek
Feb 1, 2014·Journal of the American Academy of Dermatology·Jose A PlazaMartin Sangueza
Mar 20, 2014·Acta ortopedica brasileira·Stefan Dias ZolinIvan Chakkour
Aug 12, 2014·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Bas L FransenBart J Burger
Nov 25, 2014·Journal of the Peripheral Nervous System : JPNS·Giulia RonchiStefano Geuna
Oct 27, 2015·Journal of Clinical and Diagnostic Research : JCDR·Surya Rao Rao Venkata MahipathyJayaganesh Parthasarathy
Nov 26, 2015·Muscle & Nerve·Joyeeta RoyKrzysztof A Tomaszewski
May 10, 2016·The Journal of Comparative Neurology·Meng-Lin LiaoChung-Liang Chien

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
amputation
electron microscopy
fluorescence macroscopy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Related Papers

Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova
B M Gekht, S S Nikitin
Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
B T JohnstonR F Mark
Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie
R STAMPFLI
Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D: Sciences naturelles
J C Mira
© 2022 Meta ULC. All rights reserved