PMID: 22573750May 11, 2012Paper

Morphological aspects of the familial Mediterranean fever

Georgian Medical News
S V Ambartsymian

Abstract

The study of clinical and morphological features of multiple organ lesions in familial Mediterranean fever (FMF) is important for identification of main morphologic lesions in thanatogenesis in parallel with the clinical manifestations. Clinical-morphological analysis of 200 patients with FMF and 60 dead from complications of FMF without renal transplantation were done. It was established that renal affection was observed in all patients, who died from complications of FMF, but the severity and nature of the observed changes were different. The kidney affections in investigated material in 3 groups were classified: amyloidosis, nonamyloid affections and glomerulitis accompanied with amyloidosis. Cardiopathic amyloidosis we established in thanatogenesis of FMF manifested with heart failure. The secondary polyorganial amyloidosis in FMF resulting in polyorganial failure revealed. The lung amyloidosis was accompanied with cardiac. Kidney affections were manifested with nonamyloid nephropathias manifested with intracapilliary mesangioproliferative or extracapillary productive glomerulonephritis, besides amyloidosis. Amyloidosis of the heart, lungs, adrenals can significantly prevail to kidney damage and be expressed at the forefron...Continue Reading

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