Morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats.

Neuroscience and Behavioral Physiology
S M GulyaevN M Kozhevnikova

Abstract

The aim of the present work was to perform a morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats. Chronic ischemia was produced in Wistar rats (weighing 160-180 g) by ligation of both common carotid arteries. Ischemic lesions were corrected by intragastric lanthanum acetate (3 mg/kg per day) throughout the experimental period. Ischemic damage to the cortex was assessed morphometrically on histological sections stained by the Nissl method. Lanthanum acetate was found to suppress the development of ischemic neuron damage in the cerebral cortex, with reductions in the numbers of hyperchromic neurons, cells with focal chromatolysis, and ghost cells, as well as an increase in the number of normochromic cells as compared with controls.

References

Jul 1, 1990·Postgraduate Medical Journal·N B Argent, D Veale
Dec 1, 1988·Biological Trace Element Research·T DasG Talukder
Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·J HornM Limburg

❮ Previous
Next ❯

Citations

Jun 24, 2009·Experimental Biology and Medicine·Ye-Bo ZhouYong-Fen Qi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.