Morphological changes during ontogeny of the canine proximal colon

Cell and Tissue Research
Sean M Ward, Shigeko Torihashi

Abstract

The development of the canine proximal colon from the completion of organogenesis through 43 days after birth was studied using light microscopy, immunofluorescence and electron microscopy. During this period the tunica muscularis increased in thickness from 42+/-6 microm in animals midway through the gestation period to 317+/-29 microm in animals 25-30 days old. This increase in thickness resulted from an increase in the number and size of smooth muscle cells in the circular and longitudinal muscle layers. The cross-sectional thickness of the circular muscle layer increased from 10+/-2 smooth muscle cells midway through the gestation period to 92+/-7 cells in animals 25-30 days old. The longitudinal layer increased in thickness from 1.5+/-1 cells in animals midway through the gestation period to 44+/-2 cells in animals 25-30 days old. Smooth muscle cells from both layers also increased in diameter and length. Ultrastructural and immunohistochemical studies suggested that many of the smooth muscle cells were undergoing development throughout the fetal period. Midway through the gestation period, the circular layer was positive for desmin-like immunoreactivity (D-LI), while both the circular and longitudinal layers were positive...Continue Reading

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Citations

Dec 22, 1999·Microscopy Research and Technique·M S Faussone-Pellegrini, L Thuneberg
Apr 13, 1999·The American Journal of Surgical Pathology·K SircarR H Riddell
Oct 16, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M SandersS M Ward
Oct 16, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E E Daniel, Y F Wang
Nov 28, 2006·Journal of Cellular and Molecular Medicine·K W Min, M Leabu
Mar 14, 2013·Congenital Anomalies·Ryozo Hashimoto
May 21, 2003·American Journal of Veterinary Research·Daniel B PaulsenRandal K Buddington
May 15, 2002·The Journal of Pediatrics·Harish J AminR Brent Scott
Mar 11, 2009·Differentiation; Research in Biological Diversity·Shigeko TorihashiToyoshi Fujimoto

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