Morphological changes in hair melanosomes by aging

Pigment Cell & Melanoma Research
Takashi Itou

Abstract

Various changes appear in hair by aging, and graying is the most remarkable one. Changes in melanocytes have been well studied as the cause; however, little is known about the change in melanosomes which have a role of carrying melanin pigments into hair shafts. Using pigmented hairs of Japanese females from their age of 4-75, I isolated melanosomes and observed them. As a result, I found a significant change in the morphology of hair melanosomes with age. They were ellipsoidal on the whole and there was no age dependence in the major axis, while the minor axis significantly increased and its frequency distribution broadened with age. The anticipated volume of the melanosome of the oldest person hairs was about twice larger than that of child hairs. This enlargement of melanosome seems to be a cause of the age-related color change in pigmented hairs from brown to black.

Citations

Aug 3, 2019·International Journal of Molecular Sciences·Takashi ItouKazumasa Wakamatsu
Aug 17, 2019·Frontiers in Cell and Developmental Biology·Leopold EckhartFlorian Gruber
Jul 1, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M A Yamazaki-NakashimadaM Saez-de-Ocariz

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