Morphological changes in Mycobacterium fortuitum induced by ofloxacin

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
H SaitoT Hirata

Abstract

Effects of ofloxacin on morphology of Mycobacterium fortuitum ATCC 6841 were studied electronmicroscopically. The cells treated with 0.2 microgram/ml (1/2 MICs) of ofloxacin at 37 degrees C for 24 h maintained normal morphology under scanning electron microscopic observations. In the ultrathin sections of the cells treated with ofloxacin under the same conditions, ribosomal granules and other cytoplasmic organellae were clearly observed, whereas the fine fibrous structures of the nuclear apparatus were not clear. On the other hand, the treatment with 0.2 microgram/ml of ofloxacin at 37 degrees C for 5 days caused elongation of the cells, and irregular, rosary-like and/or twisted features in some cells under scanning electron microscopic observations. The formation of numerous vacuole-like structures in the cytoplasm, the indistinct nuclear apparatus, and the partial destruction of the cell wall were observed in the transmission electron microscopic examinations. We conclude from this study that morphological changes in Mycobacterium fortuitum cells treated with ofloxacin seem to firstly occur in the nuclear apparatus.

References

Jun 1, 1979·Antimicrobial Agents and Chemotherapy·D F Welch, M T Kelly
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·K SatoS Mitsuhashi
Jul 29, 1961·JAMA : the Journal of the American Medical Association·R F CORPEI STERGUS

❮ Previous
Next ❯

Citations

Feb 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M T Labro, J el Benna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.