PMID: 11310506Apr 20, 2001Paper

Morphological changes in pancreatic islets of KATP channel-deficient mice: the involvement of KATP channels in the survival of insulin cells and the maintenance of islet architecture

Archives of Histology and Cytology
A WinartoT Iwanaga

Abstract

The ATP-sensitive potassium channel (KATP channel) is an essential ion channel involved in glucose-induced insulin secretion. The KATP channel is composed of an inwardly rectifying potassium channel, Kir6.2, and the sulfonylurea receptor (SUR 1); in the pancreas it is reported to be shared by all endocrine cell types. A previous study by our research group showed that Kir 6.2-knockout mice lacked KATP channel activities and failed to secrete insulin in response to glucose, but displayed normal blood glucose levels and only mild impairment in glucose tolerance at younger ages. In some aged knockout mice, however, obesity and hyperglycemia were recognizable. The present study aimed to reveal morphological changes in pancreatic islets of Kir 6.2-knockout mice throughout life. At birth, there were no significant differences in the islet cell arrangement between the knockout mice and controls. At 14 postnatal weeks glucagon cells appeared in the central parts of islets, and this image became more pronounced with aging. In animals older than 50 weeks insulin cells decreased in numbers and intensity of insulin immunoreactivity; most islets in 70- and 80-week-old mice were predominantly composed of glucagon cells and peptide YY (PYY)-c...Continue Reading

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Citations

Jan 15, 2009·Cell and Tissue Research·Ihsane MarhfourYves Guiot
Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Isabelle FlechtnerMichel Polak
Jan 25, 2014·Diabetes/metabolism Research and Reviews·Patrizia Luppi, Peter Drain
Jan 30, 2004·Diabetes Care·Bassam S Bin-Abbas, Abdullah A Al-Ashwal
Dec 24, 2009·Indian Journal of Ophthalmology·Reema BansalAmod Gupta
Nov 14, 2019·International Journal of Molecular Sciences·Mikio Hayashi

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