PMID: 3748472Jul 1, 1986Paper

Morphological changes in rat striatal boutons after chronic methamphetamine and haloperidol treatment

Neuroscience Research
Y IharaM Namba

Abstract

Dopaminergic (DA) synaptic boutons were identified in rat striatum with an electron microscopic histochemical method. In rats which developed behavioral hypersensitivity after treatment with methamphetamine (MAP) for about 2 weeks, significantly fewer DA boutons were found. This effect was specific to DA boutons without mitochondria and was not seen in boutons with mitochondria. The density of granular synaptic vesicles in DA boutons, however, did not change significantly. These morphological changes would represent a high capability of nerve cells to reorganize synaptic connections under altered chemical environments, but they could not be related uniquely to behavioral hypersensitivity, as similar effects were observed in rats treated with haloperidol which did not develop behavioral hypersensitivity. Peculiarly, the effects of MAP treatment on both behavior and DA boutons were prevented by combined administration of haloperidol.

References

Jan 1, 1973·The American Journal of Psychiatry·S H Snyder
Jan 1, 1972·Journal of Neural Transmission·H L Klawans, R Rubovits
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Hökfelt
Oct 6, 1980·Brain Research·P Weinreich, P Seeman

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Citations

Mar 15, 1988·European Journal of Pharmacology·A R Braun, T N Chase
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Dec 11, 1999·Schizophrenia Research·P J Harrison

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