PMID: 374672Feb 1, 1979Paper

Morphological changes in the endocrine pancreas in pregnant rats with experimental diabetes

The Journal of Endocrinology
F A Van AsscheW Gepts

Abstract

This present study has demonstrated that during normal pregnancy in the rat the number of beta-cells is increased (hyperplasia) and the volume of the individual beta-cells is increased (hypertrophy). During experimental diabetes, however, the endocrine pancreas has an impaired capacity to compensate during pregnancy. In the experimental diabetic pregnant rat the beta-cells cannot replicate due to the unfavourable metabolic environment. This could reflect the complications caused by diabetes during human pregnancy.

Citations

Nov 1, 1978·Diabetologia·A KervranA Jost
Jul 8, 1985·Life Sciences·H S Bender, W R Chickering
Jul 1, 1973·European Journal of Clinical Investigation·K Asplund
Aug 17, 2011·Diabetes Management·Sara ErnstAdolfo Garcia-Ocaña
Sep 1, 1987·Biochemical Pharmacology·M S Khatim, K A Gumaa
Dec 13, 2005·The International Journal of Biochemistry & Cell Biology·Brigitte Reusens, Claude Remacle
Jan 26, 2002·British Medical Bulletin·F A Van AsscheL Aerts
Apr 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T M Egan, S J Noble
Mar 25, 2009·Endocrinology·Robert L Sorenson, Todd C Brelje
Aug 28, 2018·BioResearch Open Access·Deirdre Cocks EschlerCarol J Levy
Nov 25, 2020·Experimental Biology and Medicine·Sandra K SzlapinskiDavid J Hill
Aug 14, 2020·Molecular and Cellular Endocrinology·Edson Henrique Pereira de ArrudaMárcia Queiroz Latorraca
Mar 21, 2020·Current Vascular Pharmacology·Sandra K Szlapinski, David J Hill

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