PMID: 37942Jul 1, 1979

Morphological changes in the late periods of life in mice born after the induction of the graft vs. host reaction in their mothers

Biulleten' eksperimental'noĭ biologii i meditsiny
E A Fedosov, V V Zarudin

Abstract

Histological changes were studied in various organs of 1--2-year-old mice born after induction of the graft-versus-host reaction in mothers. The lymphoid tissue showed predominant atrophic changes, and a number of mice (61.2%) developed amyloidosis in the spleen and liver. The lymphoid infiltrates were found in the liver, kidneys, lungs and heart. In some cases glomerulonephritis, vasculitis and liver distrophy were recognized. Lymphoid malignancies were recorded in 17.7% of cases, wherease neoplasms in the control mice of the same age were incident only in 4.1%. Some neoplasms could be transplanted to adult F1 mice. A cell-free extract inocualted into newborn mice did not produce tumours during observational period of 14 months.

References

Apr 1, 1980·Biulleten' eksperimental'noĭ biologii i meditsiny·E A Fedosov, V V Zarudin
Mar 1, 1988·Journal of American College Health : J of ACH·D K DedrickJ R Mackenzie

Citations

Sep 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·L M MentkevichA S Shevelev
Jun 1, 1969·Biulleten' eksperimental'noĭ biologii i meditsiny·R F Averkina, O E VIAZOV
Dec 1, 1959·Biulleten' eksperimental'noĭ biologii i meditsiny·N V LYSOGOROV, O E VIAZOV

Related Concepts

Vasculitis
Mice, Inbred CBA
Immune System Diseases
Lung
Amyloidosis
Spleen
Neoplasms
Tumor Lysis Syndrome
Graft Vs Host Reaction
Kidney

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