PMID: 9547856Apr 21, 1998Paper

Morphological changes in the pituitary gland of dogs chronically exposed to exogenous growth hormone

Toxicologic Pathology
P LaroqueM J van Zwieten

Abstract

Growth hormone (GH) synthesis and release from the pituitary is regulated by hypothalamic releasing hormone, insulin-like growth factor-1 (IGF-1), and somatostatin. However, the potential effects of pharmacological doses of exogenous GH on the pituitary are not well studied. To determine the potential chronic effects of exogenous GH on pituitary morphology in dogs, porcine GH (pGH) was administered subcutaneously to 3 groups of dogs (4 animals/sex/group) at doses of 0.025, 0.1, and 1.0 IU/kg/day for 14 wk. A group (4/sex) of dogs served as the vehicle control. The pituitaries from all dogs were weighed and fixed in appropriate fixatives for light and electron microscopic examination; in addition, cells of the pars distalis were quantitated by a point counting method following immunostaining to identify cells containing GH, prolactin (PRL), and adrenocorticotrophic (ACTH) hormones. Administration of pGH resulted in a statistically significant (p < or = 0.05) increased pituitary weight through the high dose. By light microscopy (LM), hypertrophy of pars distalis cells was evident in mid- and high-dose female dogs. The pituitaries of dogs given the lowest dose (0.025 IU/kg/day) of pGH were not remarkable based on weight and LM fin...Continue Reading

References

Jun 10, 1994·Gene·J A Ascacio-Martínez, H A Barrera-Saldaña
Jan 1, 1993·Hormone Research·M L HartmanM O Thorner
Jun 1, 1993·Journal of Animal Science·C J AndresP J Thomford

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Citations

Mar 21, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Georgia M FarrisSrinivasa Prahalada
Aug 10, 2000·Toxicologic Pathology·S Molon-NoblotM J van Zwieten
Apr 21, 1998·Toxicologic Pathology·C A Bondy
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Eckhardt S FerdinandiPascal Dubreuil

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