Morphological changes in the submandibular gland of aging rats

Gerodontology
B G SlavinS Bernick

Abstract

Age-related histological changes in submandibular glands of 5-, and 24-month-old Sprague-Dawley male rats were compared qualitatively using semi-thin sections of epoxy-embedded glands. Atrophy of acini and granular ducts with a concomitant hyperplasia of intercalated ducts were the dominant features seen in the 15- and 24-month-old glands compared to 5 months. In both aged groups (15 and 24 months) there appeared structures similar to terminal tubules normally seen during development. At 15 months irregular ducts consisting of a mixture of agranular cells and granular cells typical of granular ducts were found in continuity with the hyperplastic intercalated ducts. The significance of these age-related morphological changes remains speculative.

References

Jan 1, 1979·International Review of Cytology·C A Pinkstaff
Oct 1, 1985·The Anatomical Record·G ZajicekY Michaeli
Sep 1, 1971·Stain Technology·T H RosenquistS Bernick
Dec 14, 1966·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·B Tandler
Mar 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·J G Batsakis

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Citations

Sep 16, 1998·The Anatomical Record·B TandlerC J Phillips
Jan 27, 2009·Micron : the International Research and Review Journal for Microscopy·A C IssyE A Del Bel

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