Morphological changes in yeasts as a result of the action of 5-fluorocytosine.

Antimicrobial Agents and Chemotherapy
T AraiK Masuda

Abstract

The mode of action of 5-fluorocytosine on Candida albicans and Saccharomyces cerevisiae was studied with special reference to morphology and ultrastructure. Shortly after contact of yeast cells with 10 mug of 5-fluorocytosine per ml, marked enlargement of the cells occurred. The initial increase in cell size was almost the same with both yeast strains. As incubation proceeded, further increase in cell volume continued with C. albicans, whereas no further change in cell volume was observed with S. cerevisiae. An electron microscope examination of C. albicans cells after exposure to the drug revealed characteristic changes, consisting of an enlarged nucleus and a thin cell wall. The morphological changes were exactly comparable to those reported with inhibitors of deoxyribonucleic acid synthesis in mammalian cells and some bacteria.

References

Jan 1, 1965·Progress in Nucleic Acid Research and Molecular Biology·C Heidelberger
Jun 1, 1973·Antimicrobial Agents and Chemotherapy·E R BlockJ E Bennett
Aug 1, 1974·The Journal of Cell Biology·M Borgers, S De Nollin
Nov 30, 1971·Annals of the New York Academy of Sciences·S S Cohen
Aug 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·G BRECHER, F STOHLMAN
Dec 9, 1961·Biochimica Et Biophysica Acta·G M ORTH, D G CORNWELL

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.