PMID: 7090013Apr 1, 1982Paper

Morphological changes of isolated rat hepatocytes induced by imipramine

Toxicology Letters
T HasegawaM Hirata


Effect of imipramine on freshly isolated rat hepatocytes was investigated by scanning and transmission electron microscopy. Soon after the treatment of the cell with imipramine, marked changes in plasma membrane and mitochondria were found. Amitriptyrine, a structurally related drug, produced similar changes in the hepatocytes. On the other hand, Triton X-100, a nonionic surfactant, damaged the cell surface but little influence the features of the organelles.


Mar 15, 1977·European Journal of Biochemistry·J Högberg, A Kristoferson
Jan 1, 1979·Toxicology and Applied Pharmacology·H YasuharaK Arakawa
Feb 1, 1975·Biochemical Pharmacology·C O AbernathyH J Zimmerman
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M P Sheetz, S J Singer
Nov 18, 1968·JAMA : the Journal of the American Medical Association·M H ShortM E Harris
Dec 1, 1980·Neuropharmacology·C D Burgess, P Turner
Aug 5, 1961·Biochimica Et Biophysica Acta·M J FLETCHER, D R SANADI
Feb 1, 1963·Medicinski glasnik·P FILDISEVSKI


May 9, 2001·American Journal of Veterinary Research·K E PeckR H Mealey
Jul 1, 1989·Pharmacology & Toxicology·J HigakiM Hirata

Related Concepts

Plasma Membrane
Scanning Electron Microscopy
Mitochondria, Liver
August Rats
Interfacial Force
Rats, Laboratory

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