Morphological changes of neural and vascular peptides in human skin suction blister injury

The Journal of Pathology
X H GuJ M Polak

Abstract

Suction blister injury is an experimental model for the investigation of the possible derangement of dermal/epidermal interaction in injury. An extensive fibre network can be stained in skin using antisera to the pan-neuronal marker protein gene product 9.5 (PGP) and the sensory neuropeptide calcitonin gene-related peptide (CGRP), while microvessels are identifiable with antisera to the endothelial marker von Willebrand's factor (vWf) and the peptide endothelin (ET). To investigate the possible involvement of superficial cutaneous innervation and microcirculation during the repair process in injury, human skin biopsies taken at different times after suction blister injury were investigated by quantitative immunohistochemistry. Neural and endothelial changes were seen in both edge and blister areas. PGP- and CGRP-immunoreactive nerves showed an increase in both areas compared with control skin up to 6 h after injury, followed by a decrease which lasted until 72 h. This was followed by a gradual increase of both nerve types starting from the blister edge and lasting up to 8 days after injury when the values were similar to controls. Similarly, in the blister area of the skin, vWF-immunoreactive capillaries showed statistically si...Continue Reading

References

Oct 1, 1992·The British Journal of Dermatology·F Abadía MolinaJ M Polak
Jun 1, 1992·The Journal of Clinical Investigation·M D HertleF M Watt
Nov 1, 1991·The Journal of Cell Biology·M YaarB A Gilchrest
Nov 1, 1991·The American Journal of Anatomy·G D PhillipsD R Knighton
Mar 1, 1991·The Journal of Investigative Dermatology·C B BunkerP M Dowd
Nov 1, 1990·Journal of the Autonomic Nervous System·S S KaranthJ M Polak
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A HaegerstrandJ Nilsson
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Sep 1, 1987·The Journal of Investigative Dermatology·J N Mansbridge, A M Knapp
Jan 1, 1989·Annual Review of Neuroscience·P A Walicke
Jul 1, 1988·Annals of Neurology·G SobueD Pleasure
Oct 27, 1987·European Journal of Pharmacology·J Kjartansson, C J Dalsgaard
Jan 1, 1972·The Journal of Investigative Dermatology·K Nishioka, T J Ryan
Sep 1, 1973·The Journal of Investigative Dermatology·J E Wolf, R G Harrison
Mar 1, 1984·The British Journal of Dermatology·R L BarnhillT J Ryan
Apr 1, 1993·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·T E Hems, M A Glasby

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Citations

Aug 6, 2003·Life Sciences·Agnese FerrettiFranco Mosca
Aug 1, 1997·Acta histochemica·E SchulzeR H Funk
Mar 26, 1998·Plastic and Reconstructive Surgery·T KangesuI M Leigh
Dec 1, 1995·Experimental Dermatology·D de BerkerS Burge
Oct 19, 2010·Journal of Anatomy·Gemma BuckleyMark W J Ferguson
Aug 22, 2006·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·J HendersonM W J Ferguson
Sep 11, 2002·Developmental Biology·Damien BatesDonald F Newgreen
Aug 13, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·V KoivukangasA Oikarinen
Jan 16, 2009·Journal of Neurogenetics·Christine N SerwayJ Steven de Belle

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