Jan 1, 1977

Morphological characteristics of acute alcoholic hepatitis

Arkhiv patologii
G K MirodzhovR Ia Karimova

Abstract

Liver biopsies from 60 patients with acute alcoholic hepatitis (AAH) developing against the background of steatosis, chronic hepatitis and cirrhosis were studied histologically, histochemically and electron microscopically. AAH is characterized by necrosis of hepatocytes with deposition of alcoholic hyalin, obesity of the organ, and polymorphonuclear leukocyte infiltration. Hyperplasia of the smooth endoplasmic reticulum, the appearance of megamitochondria, and an increased amount of peroxisomes reflect the participation of MEOS and the catalase system in alcohol metabolism with a progressive decrease in the activity of alcoholdehydrogenase. Acute alcoholic hepatitis is a connecting link between steatosis and cirrhosis of the liver in which the accompanying autoimmune mechanism and microcirculation disorder followed by activation of lipofibroblasts are conducive to the progression of the pathologic process.

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Mentioned in this Paper

Necrosis
Alcohol Oxidoreductases
Fatty Liver
Mitochondria, Liver
Liver Glycogen
Acute Disease
Hepatitis, Alcoholic
Zyderm
Obesity
Electron Microscopy

About this Paper

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