Morphological characteristics of cardiac calcium release units in animals with metabolic and circulatory disorders.

Journal of Muscle Research and Cell Motility
Kelly F McGrathH Takekura

Abstract

Metabolic and circulatory disorders such as diabetes and hypertension are associated with cardiac dysfunction. Research on these types of experimental animals has observed abnormal calcium (Ca(2+)) sparks and waves in cells; a potential mechanism altering excitation-contraction (e-c) coupling in the myocardium. The e-c coupling depends on the intricate spatial relationship between the sarcolemma and sarcoplasmic reticulum calcium release units (CRU's). The objective of this study was to assess for a presence or absence of abnormalities in CRU's from type II diabetic and hypertensive rat models. Myocardial tissue underwent perfusion fixation followed by selective staining of the CRU's and the features observed using a high voltage electron microscope. Results revealed both diabetic groups had significant increases in body weight, a tendency toward an enlarged heart, and a significant disruption of the CRU's and displacement of transverse (t)-tubules in a longitudinal direction. The hypertensive model characteristically showed a dramatic increase in heart size, a significant increase in disrupted CRU's and a tendency towards longitudinal t-tubule orientation. We propose the two disorders of diabetes and hypertension have a simila...Continue Reading

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Citations

Jun 24, 2011·Proceedings. Biological Sciences·Michael IbrahimCesare M Terracciano
Mar 1, 2015·Biophysics Reviews·K Walweel, D R Laver
Jan 9, 2021·The FEBS Journal·Kirstie A De Jong, Viacheslav O Nikolaev
Sep 21, 2011·Journal of Molecular and Cellular Cardiology·Qinghai TianLars Kaestner

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