Morphological consequences of myelination in the human retina

Experimental Eye Research
Thomas FitzGibbon, Zoran Nestorovski

Abstract

Intraretinal myelination of ganglion cell axons occurs in about 1% of humans and when observed ophthalmoscopically, appears as a white or opaque patch within the fiber layer. Previous studies of myelinated retinal tissue have largely been conducted at the light microscopic level. Three retinae with intraretinal myelination and one normal retina were obtained post-mortem and prepared for electron microscopy. The present study showed that myelinated patches in the human retina contained a mixture of unmyelinated and myelinated axons. Within this population of myelinated axons were structures which were abnormal and there were obvious signs of axonal and myelin sheath degeneration within the myelinated patches. Outside these myelin patches the retina appeared normal without signs of degeneration indicating that post-mortem degeneration prior to fixation could not account for all of the degenerative changes observed. The lack of significant numbers of macrophages and lymphocytes indicated that there was no concomitant inflammatory process within the myelin patches. The myelination present within these eyes appeared to be due to the anomalous location of oligodendrocytes. Both unmyelinated and myelinated axons had larger diameter th...Continue Reading

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Citations

Feb 24, 2001·Clinical & Experimental Ophthalmology·N WalshT FitzGibbon
Nov 12, 2013·Indian Journal of Ophthalmology·Thomas FitzGibbon, Zoran Nestorovski
Apr 30, 2009·Current Eye Research·Christian Albrecht May
Apr 12, 2008·Journal français d'ophtalmologie·F Di GiovannaG Lodato
Nov 22, 2007·Survey of Ophthalmology·Ahmad B TarabishyElias I Traboulsi
Feb 22, 2011·Journal of Neuroscience Research·Adela QuesadaCarmen Prada
Oct 5, 2015·International Ophthalmology·Luisa PierroFrancesco Bandello
Aug 17, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Sherry J BassJerome Sherman
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Apr 8, 2017·Journal français d'ophtalmologie·T LathièreG Barreau
Jul 21, 2017·Indian Journal of Ophthalmology·Serdar Ozates, Mehmet Yasin Teke
Sep 22, 2018·International Ophthalmology Clinics·Hema L RamkumarShira L Robbins
Feb 13, 2003·Eye·C L FunnellV Pai
Sep 27, 2012·Japanese Journal of Ophthalmology·T FitzGibbon, S F Taylor
Mar 15, 2018·Brain : a Journal of Neurology·Michael H ParkinsonPaola Giunti
Jul 28, 2021·BMJ Case Reports·Shrutakirty ParidaAnup Kelgaonkar
Nov 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jian YuMin Wang

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