PMID: 7034856Feb 1, 1982Paper

Morphological destruction of cultured cells by the attachment of Treponema pallidum

The British Journal of Venereal Diseases
T J FitzgeraldS G Oakes

Abstract

The incubation of Treponema pallidum with rabbit testicular cells, HEP-2 cells, human foreskin cells, rat cardiac cells, and rat skeletal muscle cells caused morphological disruption of these cultured cells. Control preparations of heat-inactivated treponemes, a high-speed supernatant in which treponemes had been pelleted, and culture medium failed to damage the tissue cells, as did viable treponemes when the cells were incubated in inverted Sykes-Moore chambers. Thus, cellular disruption is not associated with soluble treponemal, soluble inflammatory, or soluble testicular constituents but is mediated by the specific attachment of T pallidum. This organism apparently elaborates some type of toxic activity that lyses membranes: this may explain some of the histopathology of syphilitic disease.

References

Apr 1, 1972·The British Journal of Venereal Diseases·V Lauderdale, J N Goldman
Jan 1, 1973·Transactions of the New York Academy of Sciences·G T Keusch
Feb 1, 1974·The British Journal of Venereal Diseases·J A SykesA J Kalan
Sep 1, 1971·Infection and Immunity·J A Sykes, J N Miller
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·R C BrownJ A Morris
Jan 1, 1981·Annual Review of Microbiology·T J Fitzgerald
Jan 1, 1980·Journal of Receptor Research·K Eiklid, S Olsnes
Jul 1, 1957·British Journal of Industrial Medicine·D TURNER

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Citations

Jan 19, 2006·Clinical Microbiology Reviews·Rebecca E Lafond, Sheila A Lukehart
Apr 22, 2003·Infection and Immunity·Caroline E Cameron
Aug 1, 1982·The British Journal of Venereal Diseases·L A RepeshR S Pozos
Oct 1, 1984·The British Journal of Venereal Diseases·G H WongS Graves
Dec 23, 1998·FEMS Microbiology Reviews·G M WeinstockS J Norris

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