PMID: 9178377Apr 1, 1997Paper

Morphological determinants of peripheral lung mechanical changes induced by capsaicin

Respiration Physiology
M DolhnikoffM A Martins

Abstract

We studied the morphological elements associated with airway and pulmonary tissue responses to capsaicin in mechanically ventilated guinea pigs. Lungs were excised and frozen in liquid nitrogen 3 and 20 min after capsaicin infusion (1 or 100 micrograms/kg i.v.). Using image analysis, we obtained contraction index (CI) and peribronchial edema area (CUFF) for both central (C) and peripheral airways (P). We also assessed alveolar size (mean linear intercepts, Lm) and tissue distortion (standard deviation of the number of intercepts, SDI). Multiple regression analysis showed significant associations between pulmonary tissue resistance (Rti) and CUFFP (p < 0.001); pulmonary dynamic elastance and SDI (p = 0.002); and airway resistance and CUFFC (p < 0.0001). Our results suggest that increases in Rti observed in guinea pigs after capsaicin infusion are primarily dependent on changes in the small airways, mainly peribronchiolar edema; the increase in lung elastance is related to distortion of parenchymal tissues; and large airway edema contributes significantly to airway resistance.

References

Dec 1, 1987·The American Review of Respiratory Disease·J M LundbergA Anggård
Jul 1, 1988·The American Review of Respiratory Disease·A L JamesP D Paré
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergK Folkers
Dec 1, 1982·Acta Physiologica Scandinavica·J M Lundberg, A Saria
May 1, 1994·Experimental Lung Research·M L GarciaM A Martins
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·T NagaseM S Ludwig
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May 1, 1994·American Journal of Respiratory and Critical Care Medicine·T NagaseM S Ludwig
Feb 1, 1993·The American Review of Respiratory Disease·M A MartinsP H Saldiva

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