PMID: 3213506May 1, 1988Paper

Morphological differences in hearts of rats well adapted and poorly adapted to chronic hypoxia

Acta Pathologica Japonica
M OgataT Kobayashi

Abstract

We carried out an experiment to analyze morphological differences in hearts of rats well adapted and poorly adapted to chronic hypoxia. Male and female Wistar rats, 1 week, 4 weeks and 9 weeks old, were employed on the assumption that adaptive ability was dependent on age and sex. These rats were raised at an altitude of 2,400 m and were kept for 7 to 9 weeks. Control groups were maintained at an altitude of 600 m during the same period of time. Each group consisted of 4 to 6 rats. At the end of the experiment, body weight, heart weight, ratio of heart weight to body weight and hematocrit were measured, and ventricular wall thickness, myocardial fiber diameter, capillary supply and mitochondria were morphometrically studied. Of the 6 experimental groups, the 4-week-old male rats (M2) had the highest body weight, as compared with the other experimental groups. In addition, relative to these other experimental groups, the following features were found for M2. Heart weight was intermediate, heart weight/body weight ratio was low and hematocrit was also low. Ventricular wall thickness was intermediate in the right ventricle (RV) and interventricular septum (IVS) but was thin in the left ventricle (LV). Myocardial fiber diameter was...Continue Reading

References

Jun 1, 1974·Journal of Molecular and Cellular Cardiology·M A GoldsteinA Schwartz
Sep 1, 1982·The American Journal of Cardiology·J K Perloff
Aug 1, 1981·Circulation Research·J J MercadierK Schwartz
Jul 1, 1957·The American Journal of Physiology·D V TAPPANA HURTADO
Jul 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·A KERRE J FOSTER

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