Morphological Differences in the Vertebrae of Scoliosis Secondary to Neurofibromatosis Type 1 With and Without Paraspinal Neurofibromas

Spine
Zongshan HuZezhang Zhu

Abstract

A retrospective study. Aim of the study was to investigate morphological differences in the vertebrae of scoliosis secondary to neurofibromatosis type 1 (NF1-S) with and without paraspinal neurofibromas and to identify the relationship between paraspinal neurofibromas and vertebral deformity. Scoliosis is the most common orthopedic manifestation of NF1. Erosion or infiltration of the bone by localized neurofibromas was suggested as one of the primary etiology for the vertebral deformity. One hundred fourteen patients with NF1-S were classified into spinal tumor (ST) group and nontumor (NT) group with respect to the presence of paraspinal neurofibromas. The curve pattern, curve magnitude, the shape and location of paraspinal neurofibromas, and various kinds of morphological changes of vertebrae were evaluated by complete radiographs were compared between the two groups to determine whether the presence of paraspinal neurofibromas could be associated with a more severe vertebral deformity. The ST and NT groups included 54 patients (age, 16.8 ± 5.5 years) and 60 patients (age, 17.3 ± 4.2 years), respectively. The Cobb angles of the main curve were 72.3° ± 20.6° and 65.4° ± 19.4° for the ST and NT groups, respectively. No significa...Continue Reading

References

Oct 1, 1976·Acta Orthopaedica Scandinavica·S M Rezaian
Aug 1, 1992·Spine·B A AkbarniaD Chalk
May 1, 1990·Journal of Medical Genetics·M Littler, N E Morton
Dec 1, 1988·Spine·T R TrammellD B Reed
Apr 1, 1970·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·A C Kittleson, L W Lim
Jan 1, 1970·Archivio Putti di chirurgia degli organi di movimento·P G Marchetti, A Faldini
Feb 7, 1998·Spine·H W Kim, S L Weinstein
Mar 12, 2002·The Journal of Bone and Joint Surgery. American Volume·Ulf R LiljenqvistHenry F H Halm
Jan 24, 2003·AJR. American Journal of Roentgenology·Pek-Lan KhongGaik-Cheng Ooi
Dec 1, 2004·Journal of Spinal Disorders & Techniques·Manoj RamachandranAsif Saifuddin
Feb 16, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Athanasios I TsirikosM Hilali Noordeen
May 4, 2006·Journal of Pediatric Orthopedics·Alvin H Crawford, Elizabeth K Schorry
May 13, 2010·Spine·Eskandar HassanAbdul Halim Yusof

❮ Previous
Next ❯

Citations

Jul 1, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Yun MaFlorent Elefteriou
Aug 28, 2020·Journal of Pediatric Orthopedics·Jonathan J RiosUNKNOWN NFCTC Consortium
Jul 28, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Justin D BobynAaron Schindeler

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.