Morphological evidence of telocytes in human synovium

Scientific Reports
Irene RosaMirko Manetti

Abstract

A new cell type named telocyte (i.e. cell with distinctive prolongations called telopodes) has recently been identified in the stroma of various organs in humans. However, no study has yet reported the existence of telocytes in the synovial membrane of diarthrodial joints. This work was therefore undertaken to search for telocytes in the normal human synovium using transmission electron microscopy, immunohistochemistry and immunofluorescence. Ultrastructural analyses demonstrated the presence of numerous spindle-shaped telocytes in the whole synovial sublining layer. Synovial telocytes exhibited very long and thin moniliform telopodes and were particularly concentrated at the boundary between the lining and sublining layers and around blood vessels. Light microscopy confirmed the presence of CD34-positive telocytes in the aforementioned locations. Moreover, synovial telocytes coexpressed CD34 and platelet-derived growth factor receptor α. Double immunostaining further allowed to unequivocally differentiate synovial telocytes (CD34-positive/CD31-negative) from vascular endothelial cells (CD34-positive/CD31-positive). The in vitro examination of fibroblast-like synoviocyte primary cultures revealed the coexistence of different ce...Continue Reading

References

Oct 1, 1992·Arthritis and Rheumatism·L S WilkinsonJ C Edwards
May 1, 1995·Annals of the Rheumatic Diseases·N A Athanasou
Apr 19, 2000·Archives of Histology and Cytology·T IwanagaK Nozawa-Inoue
Aug 18, 2001·Arthritis and Rheumatism·C De BariF P Luyten
Aug 1, 1962·The Journal of Cell Biology·P BARLANDD HAMERMAN
Dec 25, 2003·Archives of Histology and Cytology·Kayoko Nozawa-InoueTakeyasu Maeda
Mar 3, 2010·Immunological Reviews·Beatrix Bartok, Gary S Firestein
Oct 28, 2010·Journal of Cellular and Molecular Medicine·Daniele BaniMaria-Simonetta Faussone-Pellegrini
Nov 17, 2010·The Journal of Rheumatology·Tamara Hermida-GómezFrancisco Javier Blanco
May 26, 2011·Journal of Cellular and Molecular Medicine·L M PopescuB O Popescu
Jul 26, 2011·Journal of Cellular and Molecular Medicine·Florina M BojinVirgil Paunescu
Jan 24, 2012·Best Practice & Research. Clinical Rheumatology·Hans P Kiener, Thomas Karonitsch
Jan 27, 2012·The Open Rheumatology Journal·Malcolm D Smith
Feb 10, 2012·Pancreas·Mihnea I Nicolescu, Laurentiu M Popescu
Feb 22, 2012·Cell and Tissue Research·Mihaela Gherghiceanu, Laurentiu M Popescu
Sep 12, 2012·Journal of Translational Medicine·Yonghua ZhengXiangdong Wang
Sep 27, 2012·Journal of Cellular and Molecular Medicine·Sanda M CreţoiuLaurentiu M Popescu
Nov 6, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Artur PasternakPiotr Thor
Feb 8, 2013·Journal of Cellular and Molecular Medicine·Lara S CorradiSebastião R Taboga
Mar 1, 2013·Journal of Cellular and Molecular Medicine·Mirko ManettiLidia Ibba-Manneschi
Apr 30, 2013·Journal of Cellular and Molecular Medicine·Lucio Díaz-FloresJuan F Madrid
Oct 25, 2013·Journal of Cellular and Molecular Medicine·Maria-Giuliana VannucchiMaria-Simonetta Faussone-Pellegrini
Jan 21, 2014·Acta histochemica·Mugurel Constantin RusuVasile Sorin Mănoiu
Sep 27, 2014·Journal of Cellular and Molecular Medicine·Emanuel T FertigLaurentiu M Popescu
Oct 7, 2014·Journal of Cellular and Molecular Medicine·Mirko ManettiLidia Ibba-Manneschi
Nov 5, 2014·Biomolecular Concepts·Sanda M Cretoiu, Laurentiu M Popescu
Jan 21, 2015·Journal of Cellular and Molecular Medicine·Valeriu B Cismaşiu, Laurentiu M Popescu
May 29, 2015·Current Stem Cell Research & Therapy·Maria-Giuliana VannucchiMaria-Simonetta Faussone-Pellegrini
Jun 11, 2015·Journal of Cellular and Molecular Medicine·Yihua BeiJunjie Xiao
Jun 18, 2015·Journal of Cellular and Molecular Medicine·Qiulian ZhouJunjie Xiao
Jul 16, 2015·Journal of Cellular and Molecular Medicine·Radu AlbulescuLaurentiu M Popescu
Jan 26, 2016·Seminars in Cell & Developmental Biology·Anja M BoosRaymund E Horch
Jan 26, 2016·Seminars in Cell & Developmental Biology·Lidia Ibba-ManneschiMirko Manetti
Jan 26, 2016·Journal of Cellular and Molecular Medicine·Hui ZhangXiaoquan Guo
Mar 26, 2016·Seminars in Cell & Developmental Biology·Lawrence EdelsteinJohn Smythies
May 24, 2016·Seminars in Cell & Developmental Biology·Pallavi Bhattaram, Unnikrishnan Chandrasekharan
Jul 28, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Frank A Wollheim
Aug 17, 2016·International Journal of Molecular Sciences·Dragos CretoiuSanda M Cretoiu
Aug 30, 2016·Seminars in Cell & Developmental Biology·Dragos CretoiuSanda Maria Cretoiu
Nov 1, 2016·Advances in Experimental Medicine and Biology·Lidia Ibba-ManneschiMirko Manetti
Nov 1, 2016·Advances in Experimental Medicine and Biology·Joanna DawidowiczKrzysztof Maksymowicz

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Citations

Jun 25, 2019·Journal of Cellular and Molecular Medicine·Shinan LiShaoheng He
Aug 16, 2019·Clinical Science·Manuela DicarloMonica Mattioli-Belmonte
Mar 8, 2019·Scientific Reports·Sérgio Luis FelisbinoLuis Antônio Justulin
Aug 23, 2020·International Journal of Molecular Sciences·Eloisa RomanoMirko Manetti
Aug 20, 2020·Cell Biology International·Bruno D A SanchesHernandes F Carvalho
Dec 9, 2020·Scientific Reports·Bruno Domingos Azevedo SanchesHernandes F Carvalho
Dec 23, 2020·Journal of Cellular and Molecular Medicine·Irene RosaMirko Manetti
Dec 24, 2020·International Journal of Molecular Sciences·Lucio Díaz-FloresLucio Díaz-Flores
May 23, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Anca MaglaviceanuMohit Kapoor
Jul 14, 2021·The Prostate·Bruno D A SanchesSebastião R Taboga
Oct 16, 2021·The Journal of Clinical Investigation·Kevin WeiMichael B Brenner

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Methods Mentioned

BETA
transmission electron microscopy
light microscopy
fluorescence microscopy

Software Mentioned

ImageJ
Leica LAS
Jeol
Adobe Photoshop CS6

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