PMID: 9450535Feb 5, 1998Paper

Morphological features of neurons containing calcium-binding proteins in the human striatum

The Journal of Comparative Neurology
Lucía PrensaA Parent

Abstract

An immunohistochemical approach was used to characterize the morphological phenotype of neurons containing the calcium-binding proteins calretinin (CR), parvalbumin (PV), or calbindin-D28k (CB) in the normal human striatum. The protein CR occurs in at least four morphologically distinct types of neurons. Apart from the numerous medium-sized aspiny interneurons and the less abundant giant aspiny interneurons, CR also labels some medium-sized spiny neurons morphologically identical to striatal projection neurons. This finding indicates that CR is not only confined to striatal interneurons but also may be involved in the function of certain projection neurons. Some small and peculiar bushy-like aspiny neurons also are enriched with CR. These neurons could correspond to the dwarf or neurogliform neurons first described by Ramón y Cajal (1911). Three types of PV-immunoreactive striatal neurons can be visualized in the human striatum: 1) the common medium-sized aspiny leptodendritic neurons, 2) some smaller and profusely arborized aspiny neurons, and 3) a few large and intensely stained neurons with conspicuously beaded and poorly branched dendrites. The protein CB labels virtually all medium-sized spiny projection neurons located in...Continue Reading

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Citations

Sep 16, 2005·The International Journal of Neuroscience·Orlando Torres-FernándezHernán J Pimienta
Sep 20, 2008·Neuroscience Research·Mireille MassouhAndré Parent
Jan 6, 1999·The European Journal of Neuroscience·G SancesarioG Bernardi
Mar 28, 2018·CNS Neuroscience & Therapeutics·Anton Reiner, Yun-Ping Deng
Nov 20, 2018·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Ivan GrbatinićNebojša Milošević
Aug 30, 2007·Journal of Neural Transmission·J BernácerJ M Giménez-Amaya
Apr 18, 2020·The Journal of Comparative Neurology·Pablo Vázquez-BorsettiFabián César Loidl

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