Morphological identification of right ventricular failure in cases of fatal pulmonary thromboembolism.

International Journal of Legal Medicine
Tony FracassoAndreas Schmeling

Abstract

Pulmonary thromboembolism is a life-threatening event potentially determining right ventricular failure. Even if the pathophysiology of this phenomenon has been widely investigated, no morphological demonstration of right ventricular ischemic damage determining right ventricular failure in cases of fatal pulmonary embolism has been reported till now. We performed an immunohistochemical investigation with the markers fibronectin and C5b-9 in 26 cases of fatal pulmonary thromboembolism (16 ♀, 10 ♂, mean age 56.4 years), as well as in 25 cases of myocardial infarction (16♀, 9♂, mean age 60.8 years) and 20 cases of hanging (3♀, 17♂, mean age 40.8 years). In each case, at least one tissue slide from both cardiac ventricles (free wall of the right ventricle, anterior and/or posterior wall of the left ventricle) was prepared. The reactions were semiquantitatively classified and the groups compared. In the study group, the occurrence of ischemic changes at the right ventricle was significantly higher than in cases of myocardial infarction and global hypoxia due to hanging. The determining aspect of the immunohistochemical examination is the identification of the prevalent ischemic lesion at the right ventricle compared to the left one....Continue Reading

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Citations

Sep 18, 2010·International Journal of Legal Medicine·Tony FracassoAndreas Schmeling
Jan 15, 2011·International Journal of Legal Medicine·Tony FracassoAndreas Schmeling
May 21, 2011·International Journal of Legal Medicine·Sara SabatassoKatarzyna Michaud
Jul 9, 2013·International Journal of Legal Medicine·F AmbrosettiC Cattaneo
Jan 17, 2016·Forensic Science International : Synergy·T FracassoA Schmeling
Feb 5, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tony FracassoAndreas Schmeling
Jul 10, 2016·International Journal of Legal Medicine·Sara SabatassoValentin Djonov
Jan 25, 2018·International Journal of Legal Medicine·Aleksandra AljaknaSara Sabatasso
Nov 1, 2017·International Journal of Legal Medicine·Birthe HeitkötterDaniel Wittschieber
May 13, 2017·International Journal of Legal Medicine·Sara SabatassoTony Fracasso

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