Jul 1, 1977

Morphological investigations of extrahepatic disorders after porta-caval end-to-side-anastomosis in rats (author's transl)

Zeitschrift für Gastroenterologie
U RasenackH Liehr


Disorders of the central nervous system were found in 150 rats five monthds after en-to-side-porta-caval anastomosis consisting of vacuolisated cytoplasma of gangliacells and reactions of the glia comparable with the Alzheimer-glia-type II. Since these disorders are consistent with those in patients with liver cirrhosis but induced in these experiments by a porta-caval anastomosis alone, they are proposedly independent from liver disease itself. It is discussed whether disorders in glucose homeostai may be of pathogenetic relevance. Atrophy of tests, found in the late postoperative phase and erosions or ulcers of gastric mucosa as well as nephrolithiasis with hydronephrosis as consequence, the latter occuring independently from the time after operations, are proposedly due to the porta-caval anastomosis, too.

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Mentioned in this Paper

Glucose Metabolism Disorders
Cholestasis, Extrahepatic
Liver Diseases
CNS Disorder
Stomach Diseases
Testicular Diseases
Surgical Portacaval Shunt
Alzheimer Disease 2

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