Jan 1, 1975

Morphological manifestations and morphogenesis of the graft vs. host reaction in the brain of F1 hybrids following the administration of parental lymphoid cells and its effect on tumor inoculation

Arkhiv patologii
V V Zarudin, V Ia Shcherbakov

Abstract

It was established that intracerebral introduction of 10 min parental cells of the spleen brought about in hybrids (CBAXC57Bl/6) F1 infiltrative-destructive changes (development of lymphocytic infiltrations, dystrophy in the nerve cells, myelin fibres and neurogliacytes) the intensity of which was found to be considerably higher in cases of injection of parental spleen cells from specifically sensitized donors. Spleen cells of mice CBA produced much greater changes as compared with those produced by spleen cells of mice C57Bl/6. Inoculation into the mice brain of 10 mln of spleen cells together with tumour in a dose of 1500 cells produced a clear cut inhibitory effect on the tumour growth, this effect being more pronounced following introduction of sensitized cells of the spleen of mice CBA.

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Mentioned in this Paper

Mice, Inbred CBA
C57BL/6 Mouse
Spleen
Myelin Sheath
Neurons
Brain
Lymphoid Cells
Neoplasms
Neoplasm Transplantation
Tumor Lysis Syndrome

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