Morphological skin ageing criteria by multiphoton laser scanning tomography: non-invasive in vivo scoring of the dermal fibre network

Experimental Dermatology
Martin Johannes KoehlerM Kaatz

Abstract

Morphological changes in the dermal collagen and elastin fibre network are characteristic for skin ageing and for pathological skin conditions of the dermis. To characterize pathological and physiological conditions by multiphoton laser scanning tomography (MLT) in vivo, it is necessary to investigate and identify morphological alterations related to ageing. In vivo MLT was used to image two-photon excited autofluorescence (AF) and second harmonics generation (SHG) in human dermis of 18 volunteers of different ages. Criteria for the evaluation of age-dependent morphological changes in MLT images were fibre tension and morphology, network pattern, clot formation and image homogeneity. These criteria were weighted and a score was calculated. The resulting MLT-based Dermis Morphology Score is correlated with age (R2 = -0.90) and with the previously published SHG to AF Ageing Index of Dermis (R2 = 0.66). The two groups of young (age 21-38) and old (age 66-84) volunteers showed a significant difference in MLT score values (P < 0.001). We could demonstrate an in vivo relationship between morphological characteristics of human dermis assessed by MLT and age. The present score allows the semi-quantitative evaluation of specific morphol...Continue Reading

References

Nov 1, 1991·Journal of the American Academy of Dermatology·R WarrenG M Ridder
Sep 1, 1986·The Journal of Investigative Dermatology·V L ChenR Timpl
Dec 1, 1986·The Journal of Cell Biology·L Y SakaiE Engvall
Jun 1, 1995·The Journal of Investigative Dermatology·M RajadhyakshaR R Anderson
Aug 1, 1996·The British Journal of Dermatology·E F BernsteinJ Uitto
Nov 10, 1998·Archives of Dermatological Research·A HayashiS Tajima
Oct 3, 1999·The Journal of Investigative Dermatology·U Saarialho-KereM Vaalamo
Mar 29, 2002·The Journal of Investigative Dermatology·Christina S SanderJens J Thiele
Apr 23, 2002·The British Journal of Dermatology·A KnuutinenA Oikarinen
Feb 27, 2003·The Journal of Investigative Dermatology·Betty YuRobert Langer
Mar 19, 2003·Journal of Cutaneous Pathology·Klaus Sellheyer
Dec 17, 2003·The Journal of Investigative Dermatology·Alvin T YehBruce J Tromberg
Jan 21, 2004·Archives of Facial Plastic Surgery·Tapan K Bhattacharyya, J Regan Thomas
May 20, 2004·The British Journal of Dermatology·M PlaczekB Przybilla
Jun 4, 2004·The Journal of Investigative Dermatology·Praveen K VayalilSantosh K Katiyar
Sep 30, 2004·Biophysical Journal·Aikaterini ZoumiBruce J Tromberg
Jan 29, 2005·The Journal of Investigative Dermatology·Mi Hee ShinJin Ho Chung
Nov 11, 2005·The British Journal of Dermatology·E NaruK Kaji
Apr 25, 2006·Experimental Dermatology·Christian GorzelannyStefan W Schneider
May 20, 2006·The Journal of Investigative Dermatology·Frank StrackeMarc Schneider
Sep 14, 2006·Optics Letters·Martin Johannes KoehlerMartin Kaatz

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Citations

Apr 17, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Kaatz, K König
Apr 2, 2011·Analytical and Bioanalytical Chemistry·Riccardo Cicchi, Francesco Saverio Pavone
Nov 26, 2009·Obesity Surgery·Simone C OrpheuMarcos C Ferreira
Apr 12, 2011·Obesity Surgery·Daniela Francescato VeigaLydia M Ferreira
May 18, 2013·Tissue Engineering. Part B, Reviews·Luc NimeskernKathryn S Stok
Oct 7, 2009·Tissue Engineering. Part C, Methods·Olaf FritzeCsaba Harasztosi
Apr 17, 2012·Journal of Biomedical Optics·Stefan PuschmannFrank Fischer
Dec 12, 2012·Journal of Biomedical Optics·Dora Aït-BelkacemSophie Brasselet
Sep 25, 2014·BioMed Research International·Riccardo CicchiFrancesco Saverio Pavone
Sep 1, 2011·Expert Opinion on Medical Diagnostics·Martin Johannes KoehlerMartin Kaatz
Jan 30, 2009·The Journal of Investigative Dermatology·Enrico DimitrowMartin Kaatz
Jul 25, 2009·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Martin Johannes KoehlerMartin Kaatz
Nov 2, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Peter ElsnerChristos C Zouboulis
Jan 14, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Keiichi SugataYoshinori Takema
Jul 20, 2010·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Martin Johannes KoehlerMartin Kaatz
Jul 20, 2010·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·R BazinJ W Fluhr
Feb 22, 2013·The Australasian Journal of Dermatology·Laura WhellerTarl W Prow
Apr 18, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Seidenari StefaniaDunsby Christopher
May 18, 2011·The British Journal of Dermatology·L BaillieH P Soyer
Apr 2, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M J KoehlerM Kaatz
Apr 27, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Elisa BenatiStefania Seidenari
May 12, 2010·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Martin KaatzMartin Johannes Koehler
Dec 29, 2011·Dermatology Research and Practice·Stefania SeidenariChris Dunsby
Jul 30, 2014·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M J KoehlerM Kaatz
May 7, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M ZiegerM Kaatz
Jul 31, 2014·Journal of Innovative Optical Health Sciences·Elijah YewPeter T C So
Aug 10, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·V L NewtonM J Sherratt
Aug 15, 2017·Skin Pharmacology and Physiology·Carolin CzekallaMartina C Meinke
Feb 27, 2018·Experimental Dermatology·Motoki NakamuraAkimichi Morita
Apr 28, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M MorvováL Šikurová
Sep 23, 2009·Journal of Biophotonics·Riccardo CicchiFrancesco S Pavone
Nov 14, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·B HindelangU Darsow
Nov 20, 2008·Archives of Facial Plastic Surgery·Edward C Wu, Brian J F Wong
Aug 3, 2011·Optics Letters·Anthony M D LeeHaishan Zeng
Mar 9, 2017·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·S SpringerM Kaatz

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