Morphological Spectrum and Pathological Parameters of Type 2 Endometrial Carcinoma: A Comparison With Type 1 Endometrial Cancers

Curēus
Atif A HashmiAbira Imran

Abstract

Introduction Endometrial cancers (ECs) are the most common gynecological malignancies. Based on morphology and pathogenesis, ECs are segregated into type 1 and 2 ECs. Types 1 ECs are those tumors that are estrogen-driven, whereas type 2 ECs are more aggressive and are independent of hormonal status. In the proposed study, we evaluated the clinicopathological parameters of type 2 ECs and its comparison with type 1 ECs. Methods We retrospectively analyzed seven-year data from archives of pathology, Liaquat National Hospital, from January 2013 to December 2019. All patients underwent radical surgeries for diagnosed EC on endometrial biopsy. All specimens were of total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and peritoneal sampling, along with pelvic lymphadenectomy. Records regarding tumor type, grade, depth of myometrial invasion, and ovarian, omental, nodal, and parametrial involvement were assessed. Results A total of 129 cases of ECs were included in the study. The mean age of the patients was 57.6 ± 9.3 years. Majority of the cases were type 1 ECs (82.2%). The most common histological type of EC was endometrioid (82.2%) followed by serous carcinoma (10.1%). Most of the tumors were grade 1 (42...Continue Reading

References

Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Mar 15, 2013·Gynecologic Oncology·Louise A BrintonRichard Zaino
Aug 9, 2016·Journal of Mid-life Health·Flora D Lobo, Eliz Thomas
May 12, 2018·BMC Research Notes·Atif Ali HashmiMuhammad Muzzammil Edhi
Dec 15, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Robert A SoslowC Blake Gilks
Jan 3, 2019·Gynecologic and Obstetric Investigation·Jacqueline FeinbergPeter E Schwartz
Jan 8, 2019·Acta Oncologica·Suzanna HuttJayanta Chatterjee
Sep 27, 2019·Asian Pacific Journal of Cancer Prevention : APJCP·Atif Ali HashmiNaveen Faridi

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Methods Mentioned

BETA
biopsy
hysterectomy

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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