Morphological Stasis and Proteome Innovation in Cephalochordates

Genes
László BányaiLászló Patthy

Abstract

Lancelets, extant representatives of basal chordates, are prototypic examples of evolutionary stasis; they preserved a morphology and body-plan most similar to the fossil chordates from the early Cambrian. Such a low level of morphological evolution is in harmony with a low rate of amino acid substitution; cephalochordate proteins were shown to evolve slower than those of the slowest evolving vertebrate, the elephant shark. Surprisingly, a study comparing the predicted proteomes of Chinese amphioxus, Branchiostoma belcheri and the Florida amphioxus, Branchiostoma floridae has led to the conclusion that the rate of creation of novel domain combinations is orders of magnitude greater in lancelets than in any other Metazoa, a finding that contradicts the notion that high rates of protein innovation are usually associated with major evolutionary innovations. Our earlier studies on a representative sample of proteins have provided evidence suggesting that the differences in the domain architectures of predicted proteins of these two lancelet species reflect annotation errors, rather than true innovations. In the present work, we have extended these studies to include a larger sample of genes and two additional lancelet species, Asym...Continue Reading

References

Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E M Prager, A C Wilson
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A C WilsonV M Sarich
Jan 19, 2000·Trends in Biochemical Sciences·L Patthy
Oct 18, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T F Schilling, R D Knight
Sep 28, 2004·Evolution; International Journal of Organic Evolution·Benjamin M Fitzpatrick
Jul 29, 2005·Molecular Biology and Evolution·Jaime E Blair, S Blair Hedges
Sep 24, 2005·The FEBS Journal·Hedvig TordaiLászló Patthy
Aug 24, 2006·Genome Biology·Roderic GuigóMartin G Reese
Mar 9, 2007·Nature·Andrew Hendry
Jun 20, 2008·Nature·Nicholas H PutnamDaniel S Rokhsar
Sep 6, 2008·Development Genes and Evolution·Jr-Kai YuYutaka Satou
Feb 20, 2009·Genome Biology·Jennifer HarrowRoderic Guigó
Oct 13, 2011·Molecular Systems Biology·Fabian SieversDesmond G Higgins
Jul 19, 2013·Database : the Journal of Biological Databases and Curation·Alinda Nagy, László Patthy
Oct 10, 2013·Evolution; International Journal of Organic Evolution·Benjamin C Haller, Andrew P Hendry
Apr 8, 2014·Database : the Journal of Biological Databases and Curation·Alinda Nagy, László Patthy
Dec 5, 2014·PLoS Computational Biology·James F DentonMatthew W Hahn
Dec 18, 2015·Nucleic Acids Research·Robert D FinnAlex Bateman
Jul 15, 2016·Genome Biology and Evolution·Jia-Xing YueLinda Z Holland
Jun 22, 2017·Genome Biology and Evolution·Warren R Francis, Gert Wörheide
Dec 12, 2017·Developmental Biology·Vladimir Soukup, Zbynek Kozmik
Jan 11, 2018·The International Journal of Developmental Biology·Iryna Kozmikova, Jr-Kai Yu

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Datasets Mentioned

BETA
GESY01032162.1
GESY01012772.1
GETC01125846.1
GETC01084111.1
GETC01124733.1

Software Mentioned

MisPred
FixPred
Clustal Omega

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